Developmental dental anomalies have been associated with different malocclusions in various populations. This study verified this association in Brazilian non-syndromic orthodontic patients. The prevalence of dental anomalies was evaluated by examining 2,052 pretreatment records of orthodontic patients. Panoramic radiographs, study designs, intraoral photographs and medical history were collected in order to identify hypodontia, hyperdontia, microdontia, macrodontia, taurodontism, transposition, impaction, and ectopia. Epidemiological data and classification of malocclusion were also obtained. Data were analyzed using chi-square and Fisherʼs exact test (P < 0.05), and the prevalence ratio was obtained from cases that had a significant association between anomaly and malocclusion. The results showed that 27.4% of the patients evaluated had some dental anomaly, and most of them were white women aged 11-20 years. Ectopia, microdontia, impaction, and hypodontia were more prevalent in patients with Class I malocclusion. Macrodontia was the only anomaly associated with Class II division 1. Impaction was associated with Class III malocclusion, at a 1.84-times higher prevalence. In conclusion, impaction was correlated with Class I malocclusion; macrodontia showed association with Class II division 1; and impaction and ectopia were associated with Class III malocclusion in Brazilian orthodontic patients. (J Oral Sci 58, 75-81, 2016)

Correct diagnosis is essential for a successful therapeutic approach and resolution of the lesion.

No abstract

Multinucleated giant cells (MGC) are considered to be a hallmark of granulomatous inflammation; thus, they may play an essential role in the host response against pathogens, particularly Paracoccidioides brasiliensis. This study characterizes the MGC found in oral paracoccidioidomycosis and assesses the correlation of MGC with the amount of fungi within oral tissues. Twenty-six cases were included. They were classified as loose or dense granulomas, and the total MGC, including foreign-body and Langhans giant cells, besides the total and intracellular fungi, were taken into consideration. CD163 immunoexpression was performed, and CD163+ multinucleated giant cells were also quantified. Dense granulomas revealed more foreign-body type and total giant cells than loose granulomas (P < 0.05). Total giant cells showed a positive linear correlation with the CD163+ cells (P = 0.003; r = 0.56) and intracellular fungi quantification (P = 0.045; r = 0.40). Oral paracoccidioidomycosis lesions contain MGC that mainly belong to a CD163+ phenotype, also showing both Langhans and foreign-body arrangements. Additionally, the higher the presence of MGC, the higher the amount of phagocytized fungi.