This study evaluated the larvicidal activity of
Origanum majorana
Linnaeus essential oil, identified the chemical composition, evaluated the antimicrobial, cytotoxic and antioxidant potential. The larvicidal activity was evaluated against larvae of the third stage of
Aedes aegypti
Linaeus, whereas the chemical composition was identified by gas chromatography coupled to mass spectrometer, the antimicrobial activity was carried out against the bacteria
Pseudomonas aeruginosa
,
Escherichia coli
and
Staphylococcus auereus
, the antioxidant activity was evaluated from of 2.2-diphenyl-1-picryl-hydrazila sequestration and
Artemia salina
Leach cytotoxicity. Regarding to the results, the larvicidal activity showed that
O
.
majorana
L. essential oil caused high mortality in
A
.
aegypti
L. larvae. In the chromatographic analysis, the main component found in
O
.
majorana
L. essential oil was pulegone (57.05%), followed by the other components verbenone (16.92%), trans-p-menthan-2-one (8.57%), iso-menthone (5.58%), piperitone (2.83%), 3-octanol (2.35%) and isopulegol (1.47%). The antimicrobial activity showed that
E
.
coli
and
P
.
aeruginosa
bacteria were more sensitive to oil than
S
.
aureus
, which was resistant at all concentrations. Essential oil did not present antioxidant activity, but it has high cytotoxic activity against
A
.
salina
L.
This study evaluated the larvicidal activity of O. majorana essential oil, identified the chemical composition, evaluated the antimicrobial, cytotoxic and antioxidant potential. The larvicidal activity was evaluated against larvae of the third stage of Aedes aegypti, whereas the chemical composition was identified by gas chromatography coupled to mass spectrometer, the antimicrobial activity was carried out against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus auereus, the antioxidant activity was evaluated from of 2.2-diphenyl-1-picryl-hydrazila sequestration and Artemia salina cytotoxicity. Regarding to the results, the larvicidal activity showed that O. majorana essential oil caused high mortality in A. aegypti larvae. In the chromatographic analysis, the main component found in O. majorana essential oil was pulegone (57.05%), followed by the other components verbenone (16.92%), trans-p-menthan-2-one (8.57%), iso-menthone (5.58%), piperitone (2.83%), 3-octanol (2.35%) and isopulegol (1.47%). The antimicrobial activity showed that E. coli and P. aeruginosa bacteria were more sensitive to oil than S. aureus, which was resistant at all concentrations. Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. salina.
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