In silico and in vivo study of adulticidal activity from Ayapana triplinervis essential oils nano-emulsion against Aedes aegypti

Rodrigues, Alex Bruno Lobato; Martins, Rosany Lopes; Rabelo, Érica de Menezes; Matos, Jonathan Lopes de; Santos, Lizandra Lima; Brandão, Lethicia Barreto; Chaves, Renata do Socorro Barbosa; Costa, Ana Luiza Fontes de Azevedo; Faustino, Cleidjane Gomes; Sá, Dayse Maria da Cunha; Farias, Ana Luzia Ferreira; Almeida, Sheylla Susan Moreira da Silva de

doi:10.1016/j.arabjc.2022.104033

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…It is suggested that its primary constituents may be responsible for the potent anticholinesterase activity. In particular, the single compound acyphypllene, found in H. spectabile (5.37 ± 0.27%), was identified by Lobato et al to be a promising metabolite that showed signs of inhibiting acetylcholinesterase receptors [ 19 ]. According to Bonesi et al, the compound sabinene, which is found in both essential oils and is a prominent component of H. cumbalense (14.37 ± 1.64%), also exhibited high activity against AChE with an IC 50 value of 176.5 µg/mL [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Profiling of Hedyosmum cumbalense and Hedyosmum spectabile (Chloranthaceae) Essential Oils, and Their Antimicrobial, Antioxidant, and Anticholinesterase Properties

Guerrero

Cartuche

et al. 2022

Plants

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In Ecuador, Hedyosmum cumbalense and Hedyosmum spectabile are valued for their well-known aromatic characteristics and therapeutic benefits. In this study, fresh and dried leaves of these species were steam-distilled to obtain their essential oils (EOs) for chemical characterization and assessment of their antimicrobial, antioxidant, and anticholinesterase properties. Gas chromatography coupled to mass spectrometry (GC-MS) and a flame-ionized detector (GC-FID) with a nonpolar column was employed to determine the chemical composition, along with the enantioselective analysis. The antimicrobial activity was evaluated against three Gram-positive, two Gram-negative, and two sporulated fungi. The radical scavenging properties were evaluated by DPPH and ABTS assays. A total of 66 and 57 compounds were identified for H. cumbalense and H. spectabile, respectively. Two pairs of enantiomers for each species were also detected, with (1R,5R)-(+)-sabinene and (1S,5S)-(–)-sabinene found in both specimens. A poor effect against Gram-positive cocci was observed on H. cumbalense (MIC of 4000 µg/mL). Both oils displayed weak antifungal activities, exhibiting a MIC of 1000 µg/mL. H. cumbalense had a good scavenging effect assessed by the ABTS radical (SC50 = 96.02 ± 0.33 µg/mL). Both EOs showed a strong anticholinesterase potential with an IC50 value of 61.94 ± 1.04 µg/mL for H. cumbalense and 21.15 ± 1.03 µg/mL for H. spectabile.

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Section: Discussionmentioning

confidence: 99%

Chemical Profiling of Hedyosmum cumbalense and Hedyosmum spectabile (Chloranthaceae) Essential Oils, and Their Antimicrobial, Antioxidant, and Anticholinesterase Properties

Guerrero

Cartuche

et al. 2022

Plants

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“…In the kidneys, the changes observed can compromise the normal functioning of the organ, as glomerular degeneration alters normal circulation and prevents the passage of blood for filtration, remaining in the tubules and consequently obstructing them [41,49,50].…”

Section: Noteo Toxicity To Non-target Organismsmentioning

confidence: 99%

Composition and Bioactivity from the Essential Oil of Tetradenia riparia in Pathogenic Bacteria, Aedes aegypti L. (Diptera: Culicidae), and Toxicological Evaluation of Mus musculus (Rodentia: Muridae)

Rabelo,

Martins,

Rodrigues

et al. 2024

Preprint

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Objective: In this work, we evaluated the chemical composition by chromatography coupled to mass spectrometry, antimicrobial and insecticidal activity of essential oils (TrEO) and nanoeffu-sion (NTrEO) of oil from Tetradenia riparia leaves. We also evaluated the acute toxicity in Mus musculus. The results showed that S. aureus showed greater susceptibility to TrEO, with a minimum inhibitory concentration (MIC) of 125 µg.mL-1, when compared to P. aeruginosa, E. coli, which presented a MIC of 250 µg.mL-1. There was a greater toxic effect on TrEO (LC50 = 630.29 µg.mL-1) and NTrEO (LC50 = 713.68 µg.mL-1) larvae, effect on pupae (LC50 = 630.29 µg.mL-1) and NTrEO (LC50 = 713.68 µg.mL-1) and ovicide (LC50 = 631.184 µg.mL-1) and NTrEO (LC50 = 146.701 µg.mL-1) of Ae. aegypti after 24 h of exposure, when compared to other exposure periods. Chemical analysis re-vealed 20 components, aromadendrene oxide (23.47%) being the main component. Female and male mice were used to assess toxicity and oral administration of NTrEO to mice did not result in acute toxicity. Thus, the essential oil of T. riparia and its nanoemulsion have insecticidal and an-timicrobial potential for Ae. aegypti, S. aureus, E. coli, P. aeruginosa, and has a high toxicological safety threshold at the concentrations evaluated in this study.

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“…The target proteins, positive controls, and components of OBEO were input into the web server. To validate the molecular docking process, the distance between atoms of the superimposed protein (RMSD) was compared with the best conformation obtained using a computer-generated model (Liu et al, 2022;Rodrigues et al, 2022b).…”

Section: Docking Study Via Cb-dockmentioning

confidence: 99%

Evaluation of larvicidal activity of Ocimum basilicum L. essential oil on Aedes (Stegomyia) aegypti L.

Santos,

Monteiro,

Matos

et al. 2024

Cad. Pedagógico

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Aedes aegypti is a mosquito species of significant importance to public health because of its role in the spread of infections in tropical and subtropical regions worldwide. Chemical control measures are crucial for insect management. However, the widespread use of commercial insecticides has led to the development of resistance to Ae. aegypti. Therefore, alternative control measures must be explored. This study aimed to investigate the larvicidal activity and mechanism of action of Ocimum basilicum essential oil against Aedes (Stegomyia) aegypti L. The phytochemical components of the oil were identified using gas chromatography coupled with mass spectrometry analysis, which revealed that oxygenated monoterpenes, primarily Linalool and Estragole, were the major components. The essential oil demonstrated concentration-dependent larvicidal activity, with increased mortality rates at higher concentrations. The larvicidal activity of the essential oil may be enhanced, as shown by molecular docking of its phytochemical components, either individually or in combination with juvenile hormones. These findings suggest that the essential oil has the potential to be used as a larvicide for the management of Ae. aegypti populations and that the mechanism of action may involve interactions between the phytochemical components and juvenile hormones.

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In silico and in vivo study of adulticidal activity from Ayapana triplinervis essential oils nano-emulsion against Aedes aegypti

Cited by 7 publications

References 46 publications

Chemical Profiling of Hedyosmum cumbalense and Hedyosmum spectabile (Chloranthaceae) Essential Oils, and Their Antimicrobial, Antioxidant, and Anticholinesterase Properties

Chemical Profiling of Hedyosmum cumbalense and Hedyosmum spectabile (Chloranthaceae) Essential Oils, and Their Antimicrobial, Antioxidant, and Anticholinesterase Properties

Composition and Bioactivity from the Essential Oil of <em>Tetradenia riparia </em>in Pathogenic Bacteria, <em>Aedes aegypti</em> L. (Diptera: Culicidae), and Toxicological Evaluation of <em>Mus musculus </em>(Rodentia: Muridae)

Evaluation of larvicidal activity of Ocimum basilicum L. essential oil on Aedes (Stegomyia) aegypti L.

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