Larvicidal evaluation of the <i>Origanum majorana</i> L. Essential Oil against the larvae of the <i>Aedes aegypti</i> mosquito

Chaves, Renata do Socorro Barbosa; Martins, Rosany Lopes; Rodrigues, Alex Bruno Lobato; Rabelo, Érica de Menezes; Farias, Ana Luzia Ferreira; Araujo, Camila; Sobral, T. F.; Galardo, Allan Kardec Ribeiro; Almeida, Samanta

doi:10.1101/595900

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…The average percentage of free-radical scavenging activity of essential oils and the reference standard (ascorbic acid) by DPPH assay is shown in Figure 4a,b. According to a literature review, O. majorana EOs were found to exhibit stronger antioxidant activity in terms of smaller IC 50 values, smaller than 200 µg/mL [14,21,63,[73][74][75]. In other studies, antioxidant activity of marjoram EO was reported to be weaker, with IC 50 values greater than 200 µg/mL [41,68,76,77].…”

Section: Antioxidant Activity 261 Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

“…The essential oil of this plant has also been used for pain, gastrointestinal problems, and respiratory tract disorders [19,20]. The antiparasitic and larvicidal activities of marjoram have also been reported in several studies [21]. Moreover, majorana was reported to show antidiabetic activity [22], nephrotoxicity protective effects [23], anti-inflammatory, analgesic, and anti-pyretic activities [24].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal

Paudel

Satyal

Satyal³

et al. 2022

Molecules

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This study was conducted to examine the chemical constituents of Origanum majorana L. essential oils (EOs) that originate in Nepal, as well as their biological activities, antioxidant properties, and enantiomeric compositions. The EOs were extracted by the hydro-distillation method using a Clevenger-type apparatus and their chemical compositions were determined through gas chromatography and mass spectrometry (GC-MS). Chiral GC-MS was used to evaluate the enantiomeric compositions of EOs. The minimum inhibitory concentrations (MICs) of the essential oils were determined by the micro-broth dilution method, and the antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl scavenging assay and ferric-reducing antioxidant power (FRAP). GC-MS analysis showed the presence of 50 and 41 compounds in the EO samples, (S1) and (S2), respectively, representing the Kathmandu and Bhaktapur districts. The oxygenated monoterpenoids, along with terpinen-4-ol, were predominant constituents in both EO samples. However, the EOs from two locations showed some variations in their major components. The chiral terpenoids for two EO samples of marjoram have also been reported in this study in an elaborative way for the first time in accordance with the literature review. A hierarchical cluster analysis based on the compositions of EOs with 50 compositions reported in the literature revealed at least 5 different chemotypes of marjoram oil. The antioxidant activity for the sample (S2) was found to be relatively moderate, with an IC50 value of 225.61 ± 0.05 μg/mL and an EC50 value of 372.72 ± 0.84 µg/mL, as compared to the standard used. Furthermore, with an MIC value of 78.1 µg/mL, the EO from sample (S2) demonstrated effective antifungal activity against Aspergillus niger and Candida albicans. Moreover, both samples displayed considerable antimicrobial activity. The results suggest that EOs of Origanum majorana possess some noteworthy antimicrobial properties as well as antioxidant activity, and hence can be used as a natural preservative ingredient in the food and pharmaceutical industries.

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Section: Antioxidant Activity 261 Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal

Paudel

Satyal

Satyal³

et al. 2022

Molecules

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“…It was found that after administering 250 mg and 500 mg/kg of chicory seed extract, its cardioprotective effects were observed through inhibition of inflammatory response and oxidative stress. A study was conducted to determine the larvicidal activity of chicory against the mosquito vectors of dengue fever, malaria, and filariasis 100 A study was conducted to test and determine the antibacterial effect of O. majorana essential oil against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa 103 . For this, 2000 µg/ml of essential oil was tested against a standard of 50 µg/ml of amoxicillin and a control of 2% DMSO.…”

Section: Fig 33: Liquorice Fig 34: Phytoconstituents Of Liquoricementioning

confidence: 99%

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2022

IJPSR

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Spices are herbs used as flavoring, aromatic, and coloring agents. The culture of various countries even involves the incorporation of spices daily, not just for their culinary potential but also for the health benefits they provide. Many age-old scriptures suggest incorporating the Indian System of Spices in everyday meals to counter many diseases and keep them at bay. The fact that dietary factors play an important role in the treatment as-well-as prevention of diseases makes it all the more important to conduct research and provide scientific evidence regarding the use of culinary species as potential agents with a therapeutic effect. Such culinary spices have various active phytoconstituents, which can have many therapeutic effects and also prove to be great antimicrobial, antidiabetic, anticancer, etc. Generally, most of allopathic drugs are taken individually. Still, unlike them, the spices are consumed in combinations to provide a possible synergistic effect that would be advantageous to us. Also, due to lesser chances of side effects and incorporation of mechanisms to treat any disease right from its root, it would be safer and more practical to head for herbal drugs like these culinary spices for treating all sorts of diseases and various other ailments too. INTRODUCTION:Plants have been a valuable source of natural products for a long period of time to maintain health and wellbeing, especially with more research studies in the last decade for natural therapies. These culinary spices have been used for not only flavoring food and giving aroma but also QUICK RESPONSE CODE

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“…In this context, many studies found that O. majorana ameliorated human cancer cell lines’ growth, including human lymphoblastic leukemia cell lines, human hepatoma cell lines, in addition to experimentally induced fibrosarcoma, lung carcinoma, and hormone-dependent prostate carcinoma [ 24 , 27 , 28 ]. Previous reports also revealed the potent antiproliferative impact of O. majorana on colon cancer cells through triggering apoptosis with mitochondrial dysfunction [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation

et al. 2022

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Benign prostatic hyperplasia (BPH) is a widespread androgenic illness influencing elderly men. It is distinguished by prostatic epithelial and stromal muscle cell proliferation. Inflammation, oxidative stress, and apoptosis have all been interrelated to the development of BPH. Marjoram (Origanum majorana L.) is a herb with reported antiproliferative, proapoptotic, and antioxidative properties, which have not yet been studied in relation to BPH. Consequently, in this work, an ethanolic extract of O. majorana was prepared in two doses (250 and 500 mg/kg/day) to be injected into castrated rats after induction of a testosterone-BPH model. Testosterone propionate (TP) was subcutaneously injected (0.5 mg/kg/day) for one week after castration to induce BPH. Forty adult Wistar male rats were randomly allocated into five groups: control, BPH model, high and low O. majorana doses (250, 500 mg/kg/day), and finasteride (FN) (0.8 mg/kg/day) as a positive control. Treatment was continued with drugs/normal saline for 28 days. Rat’s body and prostate were weighed, prostate index (PI) and % of prostate growth inhibition were calculated, serum dihydrotestosterone (DHT), prostatic content of superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and malondialdehyde (MDA), DN damage, histopathological changes, immune expression of proliferating cell nuclear antigen (PCNA), caspase-3, α-SMA, and TGF-β1 were assessed. In addition, molecular quantitative PCR and ELISA analyses were performed to identify the expression of mRNAs and related proteins of both caspase-3 and TGF-β1 in prostate tissue from O. majorana-treated and untreated groups. Rats with BPH had significantly higher prostate weights and PI, higher DHT, DNA damage (8-hydroxyguanine, 8-OH-dG), and MDA levels with prominent PCNA, α-SMA, and TGF-β expression, but lower SOD, CAT, and TAC activity and caspase-3 expression. O. majorana (250 and 500 mg/kg/day)-treated groups revealed a decrease in prostate weights and PI, lower levels of DHT, suppressed oxidative stress, reduced tissue proliferation and fibrosis, and restored antioxidant and proapoptotic activity. Additionally, quantitative PCR and ELISA analysis showed that treatment with O. majorana significantly upregulated the expression of caspase-3 and downregulated the expression of TGF-β in prostate tissues of BPH rats. The data were confirmed by the immunohistological reactivity of these targeted markers in the prostate tissues. These effects were more significant with O. majorana 500 mg/mL/rat. In conclusion, the current study indicates the efficient use of O. majorana in the treatment of testosterone-induced BPH through its antiproliferative, proapoptotic, and antioxidative mechanisms.

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Larvicidal evaluation of the Origanum majorana L. Essential Oil against the larvae of the Aedes aegypti mosquito

Cited by 5 publications

References 45 publications

Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal

Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal

Untitled

Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation

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