The Toll/interleukin 1 (IL-1) receptor family plays an important role in both innate and adaptive immunity. Amino acids 527-534 as part of the loop close to the conserved box 3 are critical for recruitment of myeloid differentiation factor 88 and to a lesser extent for IL-1 responsiveness. Modeling suggests that native folding of the TIR domain may be approached by the responsive deletion mutants ⌬528 -534 and ⌬527-533, whereas the C-terminal -strand and/or ␣-helix is displaced in the nonresponsive mutant ⌬527-534.
10-Benzoyl-1,8-dihydroxy-9(10H)-anthracenones: Synthesis and Biological Properties.-In order to find novel anthralin-derivatives title compounds such as (IV) and (V) are synthesized. Many of the compounds are more potent inhibitors of the enzyme 5-lipoxygenase. Additionally, (IVc) and (IVd) have antiproliferative properties. -(MUELLER, K.; ALTMANN, R.; PRINZ, H.; Eur.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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