2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 2. Structure–activity relationships of the linker chain

Müller, Klaus; Altmann, Reinhold; Prinz, Helge

doi:10.1016/s0223-5234(01)01291-0

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…The metabolites of the 12-lipoxygenase pathway are also suggested to play an important role in the pathogenesis of psoriasis. A number of phenomena observed in this skin disease can be explained, at least in part, by the action of 12-HETE (Müller et al, 2002). Whereas the normal epidermis sythesizes predominantly 12(S)-HETE, the product derived from psoriatic skin is its enantiomer 12(R)-HETE (Müller, 1994).…”

Section: Introductionmentioning

confidence: 96%

Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists

Schneider

Bučar

2005

Phytother. Res.

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The metabolism of arachidonic acid can be catalysed by either one of two enzyme families: the cyclooxygenases or the lipoxygenases. The lipoxygenase enzymes are classed into several subcategories including 5-, 12- and 15-lipoxygenases. The 5-lipoxygenase pathway has been the major focus of study due to the pronounced pro-inflammatory role of leukotrienes and the approval of 5-lipoxygenase inhibitors and leukotriene receptor antagonists for the clinical treatment of asthma. Although less well characterized, the 12-lipoxygenase as well as the 15-lipoxygenase pathway may also play an important role in the progression of human diseases such as cancer, psoriasis and atherosclerosis. The present review article summarizes the findings from an extensive literature search on plants that have been assessed for 12- and 15-lipoxygenase inhibitory activity as well as for leukotriene receptor antagonistic properties. The results are presented in a tabular format, and a discussion about promising plant species and natural compounds as well as relevant in vitro assays are included in this article.

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Section: Introductionmentioning

confidence: 96%

Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists

Schneider

Bučar

2005

Phytother. Res.

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“…It has been demonstrated that inhibitors of 12-LOX cause tumor cell apoptosis, reduce tumor cell motility and invasiveness, or decrease tumor angiogenesis and growth [29,30]. The metabolites of the 12-LOX pathway are also suggested to play an important role in the pathogenesis of psoriasis by interfering with the disturbed AA metabolism [31,32].…”

Section: Lipoxygenasesmentioning

confidence: 99%

Triterpene Derivatives as Inhibitors of Protein Involved in the Inflammatory Process: Molecules Interfering with Phospholipase A2, Cycloxygenase, and Lipoxygenase

Braca¹,

Piaz²,

Marzocco³

et al. 2011

CDT

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Over the past years, there was an explosion in the knowledge of the protein target and molecular mechanism associated with various disease types and in the new research of drugs of natural origin. The key idea is to evaluate bioactive natural products interacting with protein domains of different genetic origin but structurally preserved to develop libraries of compounds biologically validated and selected from an evolutionistic point of view. Compared with synthetic compounds, natural products have a major number of unused scaffolds and not comparable to the libraries of synthetic compounds, and could represent a promising starting points for the discovery of new bioactive compounds. Many natural products are reported to interact with proteins involved in serious diseases, such as inflammation and cancer. Recently various chemical classes of plant secondary metabolites have emerged as potential therapeutic compounds in several inflammatory diseases. Owing to the findings that triterpenoids, a common class of plant secondary metabolites, have anti-inflammatory and anti-cancer effects on humans, the interest in their potential application in human health and disease is increasing. The present review describes anti-inflammatory triterpenes derivatives from plant and fungi reported during the last two decades in order to provide an account of this field of investigation, sorting compounds according to their targets, phospholipase A(2) (PLA(2)), cycloxygenase (COX), and lipoxygenase (LOX). The attempt is also being made to enumerate the possible leads for further synthetic and drug discovery program development.

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ChemInform Abstract: 2‐Arylalkyl‐Substituted Anthracenones as Inhibitors of 12‐Lipoxygenase Enzymes. Part 2. Structure—Activity Relationships of the Linker Chain.

Mueller¹,

Altmann²,

Prinz³

2002

ChemInform

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2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 2. Structure–activity relationships of the linker chain

Cited by 6 publications

References 33 publications

Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists

Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists

Triterpene Derivatives as Inhibitors of Protein Involved in the Inflammatory Process: Molecules Interfering with Phospholipase A2, Cycloxygenase, and Lipoxygenase

ChemInform Abstract: 2‐Arylalkyl‐Substituted Anthracenones as Inhibitors of 12‐Lipoxygenase Enzymes. Part 2. Structure—Activity Relationships of the Linker Chain.

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