The Toll/interleukin 1 (IL-1) receptor family plays an important role in both innate and adaptive immunity. Amino acids 527-534 as part of the loop close to the conserved box 3 are critical for recruitment of myeloid differentiation factor 88 and to a lesser extent for IL-1 responsiveness. Modeling suggests that native folding of the TIR domain may be approached by the responsive deletion mutants ⌬528 -534 and ⌬527-533, whereas the C-terminal -strand and/or ␣-helix is displaced in the nonresponsive mutant ⌬527-534.
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