We established a useful xenograft model for investigating the molecular mechanism underlying the bone destruction induced by OSCC in the jaw. This model will be used to investigate the precise roles of several cytokines synthesized by both cancer cells and fibroblastic cells in OSCC-associated bone destruction in the jaw.
For young growing children before the end of skeletal maturity, the growth activity of the grafted bone after hemimandibulectomy is not well-known. After an adolescence, such a patient may have facial deformity because the anterior growth point of the mandible is in the condylar neck. A 13-year-old boy was performed hemimandibulectomy with immediate mandibular reconstruction by fibula free flap (FFF) because of a huge ameloblastic fibroma. The authors evaluated the length of FFF on the images of computed tomography (CT) at 5 and 60 months after the operation and compared them by calculating growth rates. Five years after surgery, his facial appearance was symmetry and mandibular function was satisfaction. Although the mandibular bone in the contralateral side grew during 5-year follow-up, the vascularized FFF grafted in the child patient did not significantly grow. Moreover, spontaneous regeneration (SR) and the gradual osteosclerosis were confirmed on the left distal edge of the FFF on the CT imaging. The arrival of SR at the left distal edge of the FFF was considered a part of the reason to compensate the unchanging growth rate of the grafted FFF and contribute for the postoperative good functional and esthetic results.
We report a rare case of primary tongue cancer that demonstrated unusual clinical, histological, and immunohistological features. The patient was a 73-year-old man who presented with a submucosal tumor in the left side of the tongue. Treatment consisted of preoperative chemotherapy, hemi-glossectomy, and unilateral neck dissection. The tumor was located in the submucosa, independent of the overlying tongue epithelium and the salivary gland. The tumor showed infiltrative growth, with the tumor cells arranged in cord or trabecular nests without keratinization or distinct duct formation. The tumor cells were positive for pan-keratin, cytokeratin 7, and p63, but negative for other specific markers. This tumor did not match the characteristics of any defined entity; therefore, we diagnosed this lesion as a carcinoma, not otherwise specified.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.