Background: Organophosphate compounds are one of the most common agents used as poison and acts by accumulation of acetylcholine hormone at neuronal synapses resulting in the symptoms like excessive salivation, vomiting, urination, and increased serum amylase and lipase levels. APACHE 2 score along with ultrasound modality can be used to assess the acute pancreatitis. The primary aim of the study is to find correlation of serum amylase and lipase levels with duration of ICU stay and with radio-logical variables like bulky pancreas. Methods: This observational study conducted at GSVM medical college, Kanpur from December 2020 to October 2022 included 58 out of total 94 admitted patients with acute organophosphate intoxicationn on the basis of inclusion and exclusion criteria. Patients were divided in 3 groups as mild, moderate and severe using q SOFA score at the time of admission. Results: Acute organophosphate poisoning was more prevalent among 20-40 years of age group. Mean serum amylase level values in q SOFA category 0, 1, 2, 3 were 65.2, 82.0, 118.4, 329.9 IU/l respectively and that of mean serum lipase levels on day 1 of admission values were 42.0, 44.3, 38.6 and 115.5 IU/l respectively. Serum amylase levels were positively correlated with duration of ICU stay and were better predictor for acute pancreatitis. Conclusions: In this study we concluded that serum amylase is a better predictor of duration of ICU stay and acute pancreatitis in patients admitted with acute organophosphate poisoning.
Background: Liver disease impacts on hepatic synthesis of lipoproteins and lipogenesis but data on dyslipidemia during disease progression are limited. We want assess the patterns of dyslipidemia in with different etiology liver disease and its correlation with Child Pugh score from non-advanced (non-ACLD) advanced chronic liver disease (ACLD) as it is unclear how progression to ACLD impacts on dyslipidemia-associated cardiovascular risk. Aim and objectives of current study were to determine serum lipid profile in patients with chronic liver disease and its correlation with Child Pugh score. Methods: It was Cross sectional, observational study conducted in 200 patients at KPS post graduate institute of medicine, GSVM medical college, Kanpur from December 2020 to October 2022. Results: In this study mean value of Serum Cholesterol (mg/dl) was 135.25 (27.88), Serum Triglycerides (mg/dl) was 122.27 (36.29), HDL Cholesterol was 46.92 (10.36), LDL Cholesterol was 62.77 (22.59), VLDL Cholesterol was 25.62 (8.71). In this study maximum patients of chronic liver disease were due to chronic alcohol intake which account for 76% patients, 2nd most common aetiology of chronic liver disease were chronic viral hepatitis and rest were due to Wilson disease, Budd Chiari syndrome non cirrhotic portal fibrosis and cryptogenic. Patients of chronic liver disease have negative correlation on lipid profile with Child Pugh score. Conclusions: From our study its was concluded that patients having higher CTP score having more derangement (low) in serum lipid profile (specially) serum cholesterol, serum HDL, serum VLDL) than the patients having low CTP score.
Background: Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D has a central role in developing hepatic deficiency of osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their and their relationship with disease advancement in these patients according to child Pugh-score. Aims and Objectives were study of vitamin D level in patients with different aetiology of chronic liver disease and its correlation with child Pugh score. Methods: This was a cross sectional study conducted over 200 patients after applying inclusion and exclusion criteria in patients with different etiology of chronic liver disease. Results: In our study total (N=200), 152 patients of alcoholic liver disease 41 patients having deficient vitamin D, 79 having insufficient vitamin D level and 32 patients having normal vitamin D level. Patients of chronic liver disease also have negative correlation on vitamin D level with Child Pugh score. In our study it was found that patients having higher Child Pugh score there is more chance of having vitamin D deficiency and insufficiency than the patient’s low Child Pugh score. Conclusions: The prevalence of vitamin d deficiency in patients with CLD was found to be having a significant correlation with increasing CTP score with p value <0.001.
Background: A prospective study was carried out to find the variations in lipid profile in smokers when compared to non-smokers. The aim was to study the alterations in lipid profile in terms of severity of smoking. Methods: This study was carried out among 198 patients who attended medicine OPD of LLR hospital GSVM medical college Kanpur. The population was divided into 98 non-smokers and 100 smokers. The smokers were further divided into 3 groups depending on the intensity of smoking.Results: Out of 100 patients in the present study the number of subjects in mild, moderate and high smokers’ group were 33 (33%), 33 (33%), 34 (34%) respectively. Smokers had higher total cholesterol, plasma triglycerides, serum low density lipoprotein (LDL), serum very low-density lipoprotein (VLDL) and lower levels of serum high density lipoprotein (HDL) compared to non-smokers which was statistically significant.Conclusions: Increase in total cholesterol, triglycerides, LDL and VLDL were found in smokers of all age groups. Whereas HDL values showed inverse relationship. These changes were directly proportional to the severity of smoking. So, Tobacco smoking is associated with dyslipidemia which is atherogenic in nature.
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