Study of serum lipid profile in patients with chronic liver disease and its correlation with child Pugh class: a hospital based observational study in North Indian patients

Abstract

Background: Liver disease impacts on hepatic synthesis of lipoproteins and lipogenesis but data on dyslipidemia during disease progression are limited. We want assess the patterns of dyslipidemia in with different etiology liver disease and its correlation with Child Pugh score from non-advanced (non-ACLD) advanced chronic liver disease (ACLD) as it is unclear how progression to ACLD impacts on dyslipidemia-associated cardiovascular risk. Aim and objectives of current study were to determine serum lipid profile in patients with chronic liver disease and its correlation with Child Pugh score. Methods: It was Cross sectional, observational study conducted in 200 patients at KPS post graduate institute of medicine, GSVM medical college, Kanpur from December 2020 to October 2022. Results: In this study mean value of Serum Cholesterol (mg/dl) was 135.25 (27.88), Serum Triglycerides (mg/dl) was 122.27 (36.29), HDL Cholesterol was 46.92 (10.36), LDL Cholesterol was 62.77 (22.59), VLDL Cholesterol was 25.62 (8.71). In this study maximum patients of chronic liver disease were due to chronic alcohol intake which account for 76% patients, 2nd most common aetiology of chronic liver disease were chronic viral hepatitis and rest were due to Wilson disease, Budd Chiari syndrome non cirrhotic portal fibrosis and cryptogenic. Patients of chronic liver disease have negative correlation on lipid profile with Child Pugh score. Conclusions: From our study its was concluded that patients having higher CTP score having more derangement (low) in serum lipid profile (specially) serum cholesterol, serum HDL, serum VLDL) than the patients having low CTP score.