BACKGROUND AND PURPOSE:The pathophysiology of IIH remains unknown. TS stenoses have been observed in a high proportion of these patients. Stent placement to remove this potential obstruction to venous outflow has been proposed as a treatment option for patients with IIH refractory to medical treatment.

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In Reply:We thank Dr. Sakellaridis for his comments on our article (1). In response, we offer the following points.The administration of l-dopa results in the amelioration of the motor symptoms of PD. Studies have demonstrated that this improvement in motor symptoms is associated with binding of DA to DA receptors as visualized by the competitive displacement of previously administered labeled [11 C]raclopride (2) in the form of occupied striatal receptors.Stimulation of the subthalamic nucleus (STN) similarly results in amelioration of the motor symptoms of PD. Given the similarities in clinical effect between l-dopa administration and STN stimulation, we tested the hypothesis that effective STN stimulation would also result in the displacement of striatal [11 C]raclopride. We found, however, that there was no significant displacement of striatal [11 C]raclopride in response to STN stimulation, and therefore concluded-given the limitations outlined in our Discussion-that this is not the primary mechanism of action of STN stimulation. Aviva Abosch

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