Results of Multimodality Treatment for 141 Patients with Brain Arteriovenous Malformations and Seizures: Factors Associated with Seizure Incidence and Seizure Outcomes

Falero, Raúl Andrés Pérez; León, Odalys Hernández

doi:10.1227/01.neu.0000155084.47379.89

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…Peri-AVM edema is due to a combination of findings, including mass effect from engorged or thrombosed varices and/or local venous congestion. The association between seizures and the presence of a varix has been shown in multiple prior studies and it is likely that perivariceal edema and mass effect are the culprits 21 28 29…”

Section: Discussionmentioning

confidence: 90%

MR characteristics of unruptured intracranial arteriovenous malformations associated with seizure as initial clinical presentation

Benson

Chiu

Flemming

et al. 2019

J NeuroIntervent Surg

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BackgroundPatients with intracranial arteriovenous malformations (AVMs) are at increased risk of seizures.ObjectiveTo identify MRI characteristics of unruptured intracranial AVMs associated with seizures at presentation.Materials and methodsA retrospective review was completed of patients diagnosed with unruptured intracranial AVMs on MRI between January 1, 2000 and December 31, 2016. Two blinded reviewers assessed demographics, lesion locality, and imaging and architectural characteristics of AVMs and surrounding parenchyma, including, but not limited to, AVM location, venous drainage pattern, venous varix, thrombosed venous varix, long draining vein, AVM-related gliosis, peri-AVM edema, and peri-AVM T2* signal. Findings were statistically analyzed for correlation with seizure using Student’s t-test for continuous variables and Χ2 test for categorical variables.ResultsOf 165 included patients, 57/165 (34.5%) patients were imaged as part of an investigation for seizures. Patients with seizures more commonly had peri-AVM edema (36.8%, compared with 11.1% of non-seizure patients, p<0.0001), peri-AVM T2* blooming (28.1% vs 7.4%; p=0.029), a venous pouch/varix (61.4% vs 31.5%, p=0.0003), long draining vein (91.2% vs 55.6%, p<0.0001), and larger size based on Spetzler-Martin grade categorization (p=0.006). By location, AVMs located in the frontal lobe, primary motor cortex, and primary sensory cortex were associated with seizures (p=0.004, p=0.001, and p=0.006, respectively); temporal lobe location was not associated with seizures (p=0.459).ConclusionsCertain MRI characteristics of unruptured intracranial AVMs are associated with seizures. Such correlations may assist in identifying the pathophysiological mechanisms by which AVMs cause seizures.

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Section: Discussionmentioning

confidence: 90%

MR characteristics of unruptured intracranial arteriovenous malformations associated with seizure as initial clinical presentation

Benson

Chiu

Flemming

et al. 2019

J NeuroIntervent Surg

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“…According to Englot et al, the seizure time was less than 1 year, which is a predictor of seizure in a patient with cavernous malformation [ 16 ]. According to Falero and León, the short seizure time of arteriovenous malformation (AVM) was statistically significant with class I after the operation [ 17 ]. Liu et al believe that the long duration of AVM indicates poor prognosis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…GTCS attack in cavernous malformation (CM) patients indicates poor prognosis [19][20][21][22]. According to Falero and León, GTCS attack in AVM indicates a good prognosis [17]. In patients with MMD, there was no correlation between attack pattern and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for early seizure after revascularization in patients with moyamoya disease

et al. 2022

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Background To investigate the risk factors for early seizure after revascularization in patients with moyamoya disease (MMD). Methods A total of 298 patients with MMD diagnosed in our hospital from 2015 to 2018 were analyzed retrospectively. We summarized the characteristics of seizure after revascularization in patients with MMD and analyzed the predictors of early postoperative seizure. Results We identified 15 patients with MMD who developed seizures within 1 week after revascularization. According to logistic regression analysis, age (OR: 1.04, 95% CI 0.998–1.086; P = 0.060) and infarct side (OR: 1.92, 95% CI 0.856–4.290; P = 0.113) were not significantly associated with incident early seizure. Postoperative infarction (OR: 12.89, 95% CI 4.198–39.525; P = 0.000) and preoperative cerebral infarction (OR: 4.08, 95% CI 1.267–13.119; P = 0.018) were confirmed as risk factors for early seizure. Conclusions We believe that a history of preoperative infarction and new infarction are independent risk factors of early seizure in patients with MMD after revascularization.

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“…According to Englot et al, the seizure time was less than 1 year, which is a predictor of seizure in patient with cavernous malformation [16]. According to Falero and León, the short seizure time of arteriovenous malformation (AVM) was statistically signi cant with class I after operation [17]. Liu et al believes that the long duration of AVM indicates poor prognosis [18] .…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Early Seizure After Revascularization in Patients With Moyamoya Disease

Niu

Tan

Jin

et al. 2021

Preprint

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Background To investigate the risk factors of early seizure after revascularization in patients with moyamoya disease (MMD). Methods A total of 298 patients with MMD diagnosed in our hospital from 2015 to 2018 were analyzed retrospectively. We summarized the characteristics of seizure after revascularization in patients with MMD and analyzed the predictors of early postoperative seizure. Results We identified 15 patients with MMD who developed seizures within 1 week after revascularization. According to logistic regression analysis, age (OR:1.04, 95% CI 0.998–1.086; P = 0.060), and infarct side (OR:1.92, 95% CI 0.856–4.290; P = 0.113) were not significantly associated with incident early seizure. Postoperative infarction (OR:12.89, 95% CI 4.198–39.525; P = 0.000) and preoperative cerebral infarction (OR:4.08, 95% CI 1.267–13.119; P = 0.018) were confirmed as risk factors for early seizure. Conclusions We believe that history of preoperative infarction and new infarction are independent risk factors of early seizure in patients with MMD after revascularization.

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Results of Multimodality Treatment for 141 Patients with Brain Arteriovenous Malformations and Seizures: Factors Associated with Seizure Incidence and Seizure Outcomes

Cited by 5 publications

References 5 publications

MR characteristics of unruptured intracranial arteriovenous malformations associated with seizure as initial clinical presentation

MR characteristics of unruptured intracranial arteriovenous malformations associated with seizure as initial clinical presentation

Risk factors for early seizure after revascularization in patients with moyamoya disease

Risk Factors for Early Seizure After Revascularization in Patients With Moyamoya Disease

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