Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India, Philippines and SouthEast Asia. Its synonyms are M. grandiflora, M. acutifolia, M. frondosa etc. The plant is preferred as medication for the treatment of jaundice, dysentery, stomachache and influenza. The current study was based on the evaluation of antiulcer property of M. philippica leaves extract. Methods: The methods used were pylorus ligated, ethanol induced and 0.2(M) NaOH induced ulcer in rats. Results: In pylorus ligation model, aqueous extract (200 mg/kg) produced a substantial reduction in ulcer index followed by decrease in gastric volume, total acidity associated with a raise in pH, which, confirmed that tested extract of the plant act by altering the mucosal barrier Thus, the gastro protective effect of this extract may be due to the presence of flavonoid in the plant. In the same way, aqueous extract of the plant showed significant effect against ethanol induced gastric ulcer in rat as compared to methanol-treated group, which, may be due to leukotriene antagonistic effect or the inhibition of 5-lipooxygenase pathway. In NaOH induced ulcer model, aqueous extract of M. philippica revealed significant antiulcer effects on the basis of pH effect and ulcer index in rats. The anti-ulcerogenic and anti-secretory effect of the tested M. philippica leaves extracts point out its possible cyto-protective effect. Conclusion: In conclusion the aqueous extract of M. philippica leaves possess potential antiulcer activity in experimental rat models.
Diabetes mellitus, an endocrine disorder, characterized by hyperglycemia and affects a large number of people worldwide. The largest chronic metabolic disorder disease of the world, the diabetes, is almost all in a devastating form with presently over 150 million patients 1 , which has become now a life style problem. The demographic study, estimated that by 2025 the earth will have more than 300 million peoples with this invasive disorder of endocrine disease and India being with around 60 million followed by Chinese and USA 2,3. In modern medicine, no satisfactory effective therapy is still available to cure diabetes mellitus 4 .Various types of hypoglycemic agents like glibenclamide, beguanides and sulfonureas and synthetic insulin etc, meant for diabetic treatment, but its long term use have some side effect due to its toxicity (PK3456) and even these are not advisable to be safe during pregnancy. Currently available therapeutic options such as dietary modi
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