Antiulcer Property of Mussaenda philippica

Abstract

Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India, Philippines and SouthEast Asia. Its synonyms are M. grandiflora, M. acutifolia, M. frondosa etc. The plant is preferred as medication for the treatment of jaundice, dysentery, stomachache and influenza. The current study was based on the evaluation of antiulcer property of M. philippica leaves extract. Methods: The methods used were pylorus ligated, ethanol induced and 0.2(M) NaOH induced ulcer in rats. Results: In pylorus ligation model, aqueous extract (200 mg/kg) produced a substantial reduction in ulcer index followed by decrease in gastric volume, total acidity associated with a raise in pH, which, confirmed that tested extract of the plant act by altering the mucosal barrier Thus, the gastro protective effect of this extract may be due to the presence of flavonoid in the plant. In the same way, aqueous extract of the plant showed significant effect against ethanol induced gastric ulcer in rat as compared to methanol-treated group, which, may be due to leukotriene antagonistic effect or the inhibition of 5-lipooxygenase pathway. In NaOH induced ulcer model, aqueous extract of M. philippica revealed significant antiulcer effects on the basis of pH effect and ulcer index in rats. The anti-ulcerogenic and anti-secretory effect of the tested M. philippica leaves extracts point out its possible cyto-protective effect. Conclusion: In conclusion the aqueous extract of M. philippica leaves possess potential antiulcer activity in experimental rat models.

Mussaenda philippica A.Rich. Rubiaceae

“…Both chloroform and ethyl acetate extract inhibited Escherichia coli, while both ethyl acetate and ethanol extract inhibited Salmonella enteritidis. Aqueous extract of M. philippica leaves demonstrated potential antiulcer activity in experimental rat models (Jena et al 2019).…”

“…The plant parts of M. philippica are traditionally used in various folkloric medicine as a treatment for gastrointestinal disorders (Jena et al 2019). Sophy et al (2015) reported the medicinal use of M. philippica in India and other South Asian countries.…”

“…The most common compounds present in Mussaenda species are iridoids, flavonoids, and triterpenes. Various Mussaenda species were investigated and found to possess novel bioactive compounds with potential antioxidant, antimicrobial, and anti-inflammatory properties (Jena et al 2019). Kamurthy et al (2014) reported three iridoid glycosides (5-hydroxy davisioside, 4-acetoxy-7-methoxy secologanin, and 6-methoxy mussaenoside) as well as two flavones (5,7,4 0 -trihydroxy-3 0 -methoxy flavone and 5,7-dihy-droxy-6,3 0 ,4 0 -trimethoxy flavone).…”

Characterization of the Bryophyllum pinnatum leaf's Active Component and It's Antidiarrheal Potential

“…However, due to its organotoxic nature and negligible effect on decreasing blood pressure, the Bryophyllum pinnatum leaf extract is ineffective as an antihypertensive medication. 34 Rat wound models were utilised to evaluate pinnatam's efficacy in healing wounds. According to the histological analysis, it has shown good potential against wound.…”