A review on genus Millettia: Traditional uses, phytochemicals and pharmacological activities

Jena, Rasmita; Rath, Diptirani; Rout, Sudhanshu Sekhar; Kar, Dattatreya

doi:10.1016/j.jsps.2020.10.015

Cited by 31 publications

(37 citation statements)

References 48 publications

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“…The roots of M. speciosa have been known as traditional medicine materials and used for the treatment of joint pain, menoxenia, blood deficiency sallow, rheumatoid arthritis, amenorrhea, hepatitis, tuberculosis, and chronic bronchitis [15]. Several flavonoids and isoflavones, such as flavonoids naringenin, liquiritigenin, garbanzol, calycosin, and isoflavones 2 -hydroxybiochanin A, 7-hydroxy-6,4 -dimethoxyisoflavone, 2 ,5 ,7-trihydroxy-4 -methoxyisoflavone, and 6-methoxycalopogonium isoflavones A, were reported to occur in the roots of this plant [8].…”

Section: Discussionmentioning

confidence: 99%

“…Previous phytochemical studies have reported that the root extract of M. speciosa contains various constituents, including alkaloids, oleanane-type triterpene saponin, flavonoids, isoflavones, rotenoids, lignans, chalcones, and phenolic glycosides [5,[15][16][17][18][19][20][21][22]. Using UPLC-Q-TOF-MS/MS, Dandan and Xianrui characterized 21 isoflavones and 4 isoflavanones in the roots of M. speciosa [23].…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of α-Glucosidase, Acetylcholinesterase, and Nitric Oxide Production by Phytochemicals Isolated from Millettia speciosa—In Vitro and Molecular Docking Studies

Tuan

Thi

et al. 2022

Plants

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The phytochemical constituents from the roots of Millettia speciosa were investigated by chromatographic isolation, and their chemical structures were characterized using the MS and NMR spectroscopic methods. A total of 10 compounds, including six triterpenoids, two flavonoids, and two phenolic compounds, were identified from the roots of M. speciosa. Out of the isolated compounds, eight showed inhibitory effects on NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values ranging from 43.9 to 449.5 µg/mL. Ursane-type triterpenes significantly suppressed NO production compared to the remaining compounds. In addition, these compounds also exhibited remarkable inhibitory effects on α-glucosidase. Among the tested compounds, 4, 5, and 10 exhibited excellent α-glucosidase inhibition, with IC50 values ranging from 1.1 to 2.2 µg/mL. Almost all of the test compounds showed little or no acetylcholinesterase inhibition, except for 5, which showed moderate anti-acetylcholinesterase activity in vitro. The molecular docking study of α-glucosidase inhibition by 3–5 and 10 was conducted to observe the interactions of these molecules with the enzyme. Compounds 4, 5, and 10 exhibited a better binding affinity toward the targeted receptor and the H-bond interactions located at the entrance of the enzyme active site pocket in comparison to those of 3 and the positive control acarbose. Our findings evidence the pharmacological potential of this species and suggest that the phytochemicals derived from the roots of M. speciosa may be promising lead molecules for further studies on the development of anti-inflammatory and anti-diabetes drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of α-Glucosidase, Acetylcholinesterase, and Nitric Oxide Production by Phytochemicals Isolated from Millettia speciosa—In Vitro and Molecular Docking Studies

Tuan

Thi

et al. 2022

Plants

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“…However, further analytical methods should be carried out to comprehensively identify the phytochemical components of the species. For example, flavonoids, phenolics, phytosterols, saponins, alkaloids, polysaccharides, terpenoids, and resins were reported as the main phytochemicals that linked to therapeutic potentials of various Callerya species [ 16 ]. In addition, future studies focusing on isolation and purification of these potential bioactive compounds from C. speciosa should be performed to confirm their medicinal and pharmaceutical properties.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, very few published projects have evaluated the effects of C. speciosa root’s bioactivities both in vitro and in vivo. Moreover, the Callerya genus is well acknowledged for its pharmaceutical properties due to the existence of numerous valuable secondary compounds such as alkaloids, triterpenoids, coumarins, flavonoids, isoflavonoids, phenols, and phytosterols [ 16 ]. For instance, millepurone from Callerya atropurpurea and osajin from Callerya auriculata displayed antioxidant and antitumor properties [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the Callerya genus is well acknowledged for its pharmaceutical properties due to the existence of numerous valuable secondary compounds such as alkaloids, triterpenoids, coumarins, flavonoids, isoflavonoids, phenols, and phytosterols [ 16 ]. For instance, millepurone from Callerya atropurpurea and osajin from Callerya auriculata displayed antioxidant and antitumor properties [ 16 ]. In particular, C. speciosa was reported as rich in saponins, flavonoids, phenolic glycosides, polysaccharides, and formononetin, which revealed numerous biological benefits for humans [ 13 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity of Callerya speciosa Fractions against Myeloma and Lymphoma Cell Lines

et al. 2022

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Callerya speciosa is widely distributed in tropical and subtropical countries and is traditionally used for preventing numerous disorders. In this study, a bioguided fractionation of ethyl acetate extract (SE) from C. speciosa root was carried out to target antioxidant and cytotoxic activities. Of the four fractions (SE1-SE4) obtained by column chromatography, SE4 had the strongest anti-radical ability in the DPPH and ABTS assays (IC50 = 0.05 and 0.17 mg/mL, respectively), with results close to butylated hydroxytoluene (BHT), a common antioxidant agent. The cytotoxic activities against the selected cells were analyzed in this study by MTT assay. Accordingly, SE2, SE3, and SE4 significantly inhibited the viability of multiple myeloma cell lines, comprising U266 (IC50 = 0.38, 0.09, and 0.11 mg/mL, respectively) and KMS11 (IC50 = 0.09, 0.17, and 0.15 mg/mL, respectively), mantle cell lymphoma Mino (IC50 = 0.08, 0.16, and 0.15 mg/mL, respectively), and the noncancerous cell line LCL (IC50 = 0.40, 0.32, and 0.21 mg/mL, respectively). At a concentration of 125 µg/mL, SE2, SE3, and SE4 induced the cell apoptosis of U266 (32.2%, 53.2%, and 55.6%, respectively), KMS11 (36.9%, 40.8%, and 47.9%, respectively), Mino (36.6%, 39.8%, and 22.0%, respectively), and LCL (12.4%, 17.5%, and 23.5%, respectively) via annexin V assay. The dominant compounds detected in fractions by high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC-ESI-MS/MS), were identified as isoflavones. This is the first report describing C. speciosa as a promising natural source of antileukemia and antimyeloma agents, which may be useful for the development of blood cancer treatments.

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Millettia isoflavonoids: a comprehensive review of structural diversity, extraction, isolation, and pharmacological properties

Desta

El‐Aty

2022

Phytochem Rev

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There are approximately 260 known species in the genus Millettia , many of which are used in traditional medicine to treat human and other animal ailments in various parts of the world. Being in the Leguminosae (Fabaceae) family, Millettia species are rich sources of isoflavonoids. In the past three decades alone, several isoflavonoids originating from Millettia have been isolated, and their pharmacological activities have been evaluated against major diseases, such as cancer, inflammation, and diabetes. Despite such extensive research, no recent and comprehensive review of the phytochemistry and pharmacology of Millettia isoflavonoids is available. Furthermore, the structural diversity of isoflavonoids in Millettia species has rarely been reported. In this review, we comprehensively summarized the structural diversity of Millettia isoflavonoids, the methods used for their extraction and isolation protocols, and their pharmacological properties. According to the literature, 154 structurally diverse isoflavonoids were isolated and reported from the various tissues of nine well-known Millettia species. Prenylated isoflavonoids and rotenoids were the most dominant subclasses of isoflavonoids reported. Other subclasses of reported isoflavonoids include isoflavans, aglycone isoflavones, glycosylated isoflavones, geranylated isoflavonoids, phenylcoumarins, pterocarpans and coumaronochromenes. Although some isolated molecules showed promising pharmacological properties, such as anticancer, anti-inflammatory, estrogenic, and antibacterial activities, others remained untested. In general, this review highlights the potential of Millettia isoflavonoids and could improve their utilization in drug discovery and medicinal use processes. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-022-09845-w.

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A review on genus Millettia: Traditional uses, phytochemicals and pharmacological activities

Cited by 31 publications

References 48 publications

Inhibition of α-Glucosidase, Acetylcholinesterase, and Nitric Oxide Production by Phytochemicals Isolated from Millettia speciosa—In Vitro and Molecular Docking Studies

Inhibition of α-Glucosidase, Acetylcholinesterase, and Nitric Oxide Production by Phytochemicals Isolated from Millettia speciosa—In Vitro and Molecular Docking Studies

Cytotoxicity of Callerya speciosa Fractions against Myeloma and Lymphoma Cell Lines

Millettia isoflavonoids: a comprehensive review of structural diversity, extraction, isolation, and pharmacological properties

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