Studies of different partlcle slre Rradeo o f croom linked polyvinylpolypyrrolidona (Polypladone (LA. F. Corpurrt lan) ln direct coapressioa tahlet fofm~laCions show that Increase in mean particle slre enhances powder flow, dislntrprotlon and diasoliitlan altliouih hardnesr and friabll icy vcre s l i p h t l y better f o r t a b l e i s made from the finer grades. The dlrlntaffront exhlhits powerful disintegraat action at low concentratlons. It should prohebly be rarely, if ever. necessary to w e w r e than flvc per cent in o tahlet in order to achleve rapid Jlemolution. It appears iliac the use of polyviny1polypyrrolldone (P.V.P.P.) as a tablet dlulnccgront a t high concentrations my be self liritlnp; since certain properties such u powder f l a v , tahlet uelRht varletion. hardness and frlahillty start to reach unacceptable levels at high dislntegranc conccn-29 1 CoorddrC 0 1980 by M u d Dctka. Ioc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Otago on 12/28/14 For personal use only. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Otago on 12/28/14 For personal use only.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.