Effect of relative humidity and temperature on moisture sorption and stability of sodium bicarbonate powder

Analysis of the acid–base reaction between solid indomethacin and sodium bicarbonate using infrared spectroscopy, X-ray powder diffraction, and solid-state nuclear magnetic resonance spectroscopy

“…Some water may be absorbed by the reactants due to presence of defects, cavities or small amounts of amorphous material. Kuu et al [32] reported that at a temperature of 40 • C sodium bicarbonate starts to decompose slightly at 75% RH whereas negligible decomposition takes place at and below 48% RH. At and above 75% RH a mass decrease with storage time was observed which was explained by the decomposition of the substance to water, carbon dioxide and sodium carbonate.…”

Inorganic-polymer nanohybrid carrier for delivery of a poorly-soluble drug, ursodeoxycholic acid

“…Therefore, we examined the fraction of non-degraded UDCA amount in intact UDCA, UDCA-LDHs and Eudragit ® S100 coated UDCA-LDHs placed under an accelerated stability test condition (temperature, 40 • C; humidity, 75%) (Kuu et al, 1998;Waterman and Adami, 2005). As shown in Fig.…”

“…To assess the shelf life of UDCA, the accelerated stability test was performed with intact UDCA, UDCA-LDHs and Eudragit ® S100 coated UDCA-LDHs (Kuu et al, 1998;Waterman and Adami, 2005). Each of the samples was put into a glass vial and sealed, which was then placed in a constant temperature and humidity chamber (LH-1000, New Power Engineering Company, Korea).…”

Studies of the Effect of Storage Conditions on Some Pharmaceutical Parameters of Powders and Tablets

“…Generally there was an observed decrease in angle of repose over the storage period at HR above 23%. This suggests that the critical relative humidity for the powders which is the relative humidity above which a powder starts to absorbs moisture (and gain weight) 12 is 23%. Therefore, above 23% RH there was absorption of moisture and consequently increased resistance to free flow of particles of the powders.…”