Some Studies on Compression Properties of Tablet Matrices Using a Computerized Instrumented Press

Chilamkurti, Rao; Rhodes, C. T.; Schwartz, Joseph B.

doi:10.3109/03639048209052561

Cited by 25 publications

(3 citation statements)

References 5 publications

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“…It is widely used in pharmaceuticals, primarily as a binder/ diluents in oral tablet and capsule formulations where it is used in both wet or dry formulation and direct compression processes like spheronization/ pelletisation (Kibbe 2000;Enezian 1972;Chilamkurti et al 1982;Wallace et al 1983). It also has some lubricant and disintegrant properties (Omray and Omray 1986) and can be used in cosmetics and food products, especially as fat replacers.…”

Section: Introductionmentioning

confidence: 98%

Investigation of the physicochemical properties of microcrystalline cellulose from agricultural wastes I: orange mesocarp

Ejikeme

2007

Cellulose

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Orange mesocarp was obtained after removal of the epicarp and the endocarp from oranges. It was dried, pulverized and digested with 2% w/v sodium hydroxide at 80°C for 3 h. Alphaand micro-crystalline celluloses were extracted from the pulp using 17.5% w/v and 2.5 N hydrochloric acid, respectively. The physicochemical and powder properties of the extracted material were evaluated. Results obtained showed that the yield of a-cellulose from the orange mesocarp was 62.5% and that of microcrystalline cellulose 25.3%. The total watersoluble substances were 0.0018 g/g, ash 0.00035 g/g and the true density 1.760 g cm À1 , while the pH and hydration capacity are 6.61 and 2.916, respectively. Elemental analysis of the cellulose ash shows the absence of Pb and Mn and the preponderance of K, Na and Fe. The water sorption profile of the microcrystalline cellulose was also studied.

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Section: Introductionmentioning

confidence: 98%

Investigation of the physicochemical properties of microcrystalline cellulose from agricultural wastes I: orange mesocarp

Ejikeme

2007

Cellulose

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“…The drug entrapment was 95% ± 4.2%, which was higher than previously reported data for granules (Mukhopadhyay et al, 2005). It might be due to the incorporation of Avicel ® RC 591 retarding drug diffusion from pellets (Ghali et al, 1989) to calcium chloride bath, and thus retaining drug within pellet as microcrystalline cellulose has been reported to have binding action (Chilamkurti, Rhodes, & Schwartz, 1982).…”

Section: Evaluation Of Pelletsmentioning

confidence: 99%

Masking of Unpleasant Gustatory Sensation by Cross-Linking of Dehydrated Paracetamol Alginate Pellets Produced by Extrusion-Spheronization

Kulkarni

Amin

2008

Drug Development and Industrial Pharmacy

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Alginate paracetamol pellets were prepared by extrusion-spheronization process. The process variables studied were wet mass mixing time, feed rate, die opening diameter, spheronization residence time, feed rate, disk speed, and drying. The formulation variables studied were granulation fluid composition and level and drug-to-excipient ratios. The dried pellets were cross-linked with calcium chloride solution. The cross-linked pellets were evaluated for dissolution test, friability test, sphericity, flow behavior, particle size distribution, aggregation, water uptake, drug entrapment, and yield. Gustatory sensation test exhibited successful taste-masking of paracetamol by present approach.

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“…The index for the first of these was taken as the parameter proposed by Chilamkurti et al(13). The index for the first of these was taken as the parameter proposed by Chilamkurti et al(13).…”

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confidence: 99%

Relationships between flow properties, compression behaviour and mechanical characteristics of prednisone-microcrystalline cellulose tablets

Gómez-Amoza

Stanley-Wood

1991

Drug Development and Industrial Pharmacy

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This paper describes the effects on the flow properties, as well as the changes in the compression behaviour, of microcrystalline cellulose (Avicel PH 101) incorporated with prednisone together with the mechanical properties of compacts made by direct compression from mixtures of these components.There is a gradual degradation of the flow properties of the mixtures with increase proportions of prednisone. At the same time there is a close correlation between the parameters chosen to characterise the flow properties of the mixtures (unconfined yield stress, major consolidation stress and flow factor) and the compression work which influence the mechanical properties (crushing strength and friability) of compacts manufactured at low uniaxial compression forces.

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Some Studies on Compression Properties of Tablet Matrices Using a Computerized Instrumented Press

Cited by 25 publications

References 5 publications

Investigation of the physicochemical properties of microcrystalline cellulose from agricultural wastes I: orange mesocarp

Investigation of the physicochemical properties of microcrystalline cellulose from agricultural wastes I: orange mesocarp

Masking of Unpleasant Gustatory Sensation by Cross-Linking of Dehydrated Paracetamol Alginate Pellets Produced by Extrusion-Spheronization

Relationships between flow properties, compression behaviour and mechanical characteristics of prednisone-microcrystalline cellulose tablets

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