Mixed phenotype acute leukaemias (MPALs), a varied group of disorders pose a diagnostic challenge to the physicians and pathologists alike. This rare subset of acute leukaemias are characterised by the presence of blasts which express markers of more than one lineage (B-lymphoid / T-lymphoid / Myeloid lineage), making the essentiality of immunophenotyping more pertinent. MPALs are included in the acute leukaemias of ambiguous lineage under the World health organization (WHO) classification of tumours of haematopoietic and lymphoid tissues. We describe here a case report of mixed phenotype acute leukaemia (T-Lymphoid/Myeloid).
Introduction: The Pathologist's familiarity of the vast collection of benign mimickers is important in the systematic approach to the diagnosis of prostatic adenocarcinoma. Awareness of these patterns on light microscopy coupled will guide to a correct diagnosis and avoid a false-positive and false negative cancer interpretation. Aims; To study the histopathological features of mimics of prostatic adenocarcinoma, to differentiate histopathologically between mimics and adenocarcinoma. Methods: This study is done in institute of pathology, madras medical college, Chennai during the period of July 2012 to June 2014. The H&E slides from prostatic samples are viewed and various benign and premalignant mimickers are identified. Results: Out of 492 cases analysed 134 mimickers were identified. Benign mimickers are commonly found (79%) than premalignant mimickers (21%).Among benign lesions basal cell hyperplasia is the commonest followed by atrophy. Conclusion: Premalignant lesions are commonly seen in association with adenocarcinoma.
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