A Study of Benign and Premalignant Mimickers of Prostatic Adenocarcinoma

Abstract

Introduction: The Pathologist's familiarity of the vast collection of benign mimickers is important in the systematic approach to the diagnosis of prostatic adenocarcinoma. Awareness of these patterns on light microscopy coupled will guide to a correct diagnosis and avoid a false-positive and false negative cancer interpretation. Aims; To study the histopathological features of mimics of prostatic adenocarcinoma, to differentiate histopathologically between mimics and adenocarcinoma. Methods: This study is done in institute of pathology, madras medical college, Chennai during the period of July 2012 to June 2014. The H&E slides from prostatic samples are viewed and various benign and premalignant mimickers are identified. Results: Out of 492 cases analysed 134 mimickers were identified. Benign mimickers are commonly found (79%) than premalignant mimickers (21%).Among benign lesions basal cell hyperplasia is the commonest followed by atrophy. Conclusion: Premalignant lesions are commonly seen in association with adenocarcinoma.