Tishchenko reaction is the dimerization of two molecules of an aldehyde to produce symmetrical esters. These esters find wide applications in many reactions in organic synthesis. A variant of this reaction, the Evans‐Tishchenko reaction, catalyzed by SmI2 affords 1,3‐anti‐diol monoesters. This chemistry has found wide applications in natural product synthesis as it offers a mild and efficient methodology for the formation of 1,3‐diols stereoselectively. In this review, we mainly focus on recent advancements in the transition metal catalyzed and lanthanide‐actinide catalyzed Tishchenko reactions and their applications in organic synthesis covering literature from 2014 to 2019.
Multi‐component reactions have emerged as a powerful synthetic tactic for modern synthetic organic chemists for performing Diversity Oriented Synthesis. In recent years, with the advent of transition metal‐catalysed multi‐component reactions, rhodium catalysed reactions have proven to be promising candidates for delivering highly functionalized products. This review provides an overview of the rhodium‐catalysed multi‐component reactions leading to the formation of various types of compounds such as carbocycles, heterocycles of different types, spirocompounds, vicinal diols, amino acid derivatives etc.
Multicomponent reactions have received a lot of attention as a potential method for the synthesis of a wide range of complex organic molecules. Rapid development is being made in this field because of its importance in the chemical, pharmaceutical, biological, and industrial areas. Nickel is a versatile catalyst that can be used in a variety of synthetic transformations. In this review, we discuss the advancements in the field of Nickelcatalyzed multicomponent reactions, covering the literature up to 2021.
A new methodology for the synthesis of 2-aminobenzothiazoles, via CuI-catalyzed reaction between 2-bromophenyl isothiocyanate and diverse amines has been achieved. A wide range of 2-aminobenzothiazoles were produced in 27-89 % yields under the optimized condition of 5 mol% CuI in ethanol under microwave heating at 130 °C for 30 minutes. This simple and environmentally benign protocol is free from any ligands, bases and other additives.
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