Nickel‐Catalyzed Multicomponent Reactions: An Overview

Abstract

Multicomponent reactions have received a lot of attention as a potential method for the synthesis of a wide range of complex organic molecules. Rapid development is being made in this field because of its importance in the chemical, pharmaceutical, biological, and industrial areas. Nickel is a versatile catalyst that can be used in a variety of synthetic transformations. In this review, we discuss the advancements in the field of Nickelcatalyzed multicomponent reactions, covering the literature up to 2021.

Immobilized Ni on TMEDA@βSiO2@αSiO2@Fe3O4: as a novel magnetic nanocatalyst for preparation of pyrido[2,3-d:6,5-d′]dipyrimidines

“…25 Among transition metals, nickel is a versatile catalyst that able to use in a different of synthetic transformations. 25 In the literature, the advances in the eld of nickel-catalyzed multicomponent reactions are mentioned. 25 Heterocyclic compounds containing pyrido-pyrimidine framework are of importance because they are an vital moiety of many drugs and biological active substances, such as anti-inammatory, 26 antimicrobial, 27 antihypertensive, 28 antiallergic, 29 anticonvulsants, 30 calcium channel antagonists, antibacterial, 31 broblast growth factors (FGFs), 32 anti-HIV, 33 antifolate, 34 and potassium sparing agents.…”

“…[12][13][14][15] Transition metals on solid supports, and also oxides of these metals have been used as effective catalysts in various chemical reactions, including oxidation and reduction, [16][17][18][19] C-S, C-O and C-C coupling, 3,[20][21][22] and multicomponent reactions. 3,[23][24][25] Rapid development in this eld is taking place due to its importance in biological, pharmaceutical, industrial and chemical elds. 25 Among transition metals, nickel is a versatile catalyst that able to use in a different of synthetic transformations.…”

“…3,[23][24][25] Rapid development in this eld is taking place due to its importance in biological, pharmaceutical, industrial and chemical elds. 25 Among transition metals, nickel is a versatile catalyst that able to use in a different of synthetic transformations. 25 In the literature, the advances in the eld of nickel-catalyzed multicomponent reactions are mentioned.…”

“…25 Among transition metals, nickel is a versatile catalyst that able to use in a different of synthetic transformations. 25 In the literature, the advances in the field of nickel-catalyzed multicomponent reactions are mentioned. 25…”

MIL-101-NH2 -CC/Melamine@Co2+ as a novel heterogeneous catalyst for the synthesis of 2,4,5-trisubstituted imidazoles and reduction of methylene blue

“…Multicomponent reactions (MCRs) are an alternate and effective synthesis technique in which three or more reactants interact in a one-pot to produce a new complex molecular or biological product [12]. This eld is developing swiftly due to its signi cance in industrial, chemical, biological, and pharmaceutical areas [13]. MCRs offer signi cant advantages over multistep reactions as environmental friendliness, high atom economy, simple procedures, short reaction times, high selectivity, facile extraction, adjustable temperature, single-product synthesis, and high product yields [14,15].…”