Green Synthesis of 2‐Aminobenzothiazoles via Copper Catalysis under Microwave Irradiation

Abstract

A new methodology for the synthesis of 2-aminobenzothiazoles, via CuI-catalyzed reaction between 2-bromophenyl isothiocyanate and diverse amines has been achieved. A wide range of 2-aminobenzothiazoles were produced in 27-89 % yields under the optimized condition of 5 mol% CuI in ethanol under microwave heating at 130 °C for 30 minutes. This simple and environmentally benign protocol is free from any ligands, bases and other additives.

Microwave‐assisted Four‐component Cascade Reaction: One‐pot Rapid Access in the Metal‐free Synthesis of Fully Substituted Pyrroles

“…Because of the high reaction rate and high yields, microwave‐assisted reactions have gained popularity and have become an environmentally friendly method in the field of organic synthesis. Specifically, the groups of Hansen [14] and Anilkumar [15] have independently reported a methodology for the synthesis of heterocycles under microwave heating. Based on the development and use of simple raw materials and efficient tandem cyclization to synthesize various heterocyclic compounds in our group, we offered convenient and efficient access to some heterocycles of chemical and pharmaceutical importance [16,17] .…”