Introduction: Giant cell granuloma is a relatively common lesion in oral cavity. Central giant cell granuloma usually treated with surgical excision with good prognosis. However in few cases, the lesion exhibits more aggressive behaviour, high recurrence rate and poor prognosis. It is difficult to identify these cases based on histological features so the need for diagnostic markers is of paramount importance to spare patients unwanted effects. Aim:To investigate expression of Ki67, CD31, CD68 and P53 proteins in peripheral and central (aggressive and non-aggressive) giant cell granuloma and whether their expression level can be used to differentiate between aggressive and non-aggressive types. Material and methods:A total of 33 cases; 15 cases of peripheral giant cell granuloma, 10 cases of nonaggressive central giant cell granuloma and 8 cases of aggressive central giant cell granuloma were tested for Ki64, CD31, CD68 and P53 expression using immunohistochemical staining.Results: Ki67 was expressed in all study cases with significantly higher levels in aggressive variant. CD31 expressed in all cases with significantly higher levels in peripheral giant cell granuloma. CD68 was expressed in all cases with no significant differences. P53 was only identified in central giant cell granuloma with significantly higher levels in aggressive type. Conclusion:Ki67 and P53 expression might be useful markers to identify aggressive central giant cell granuloma.
Introduction: Mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland neoplasms. It represents diverse biological aggressiveness and prognosis. Estrogen receptors (ER) are activated by sex hormone Estrogen. HER2 is a member of epidermal growth factor receptors. Both ER and HER2 have been implicated in the pathogenesis and prognosis of many neoplasms particularly breast. Little is known about their role in MEC. Materials & methods: Normal salivary gland, low and high grade MEC tissue specimens were stained with anti-ER and anti-HER2 antibodies and the expression was quantified using ImagJ. Results: Normal salivary gland tissues were negative for both ER and HER2 while MEC was positive for both of them. Interestingly, ER and HER2 expression was higher in high grade MEC than in low grade MEC. Conclusion: ER and HER2 expression in MEC is correlated with its grade and may play a role in development and progression of MEC.
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