Expression of estrogen receptors (ER) and human epidermal growth factor receptor 2 (HER2) in mucoepidermoid carcinoma: Relationship to its grading

El-Attar, Radien Hm; Deraz, Elsayed Mohamed

doi:10.1016/j.tdj.2014.11.001

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In a study by El-Attar RH (El-Attar and Deraz, 2014) it was concluded that normal salivary glands do not express ErbB2. Hence, aberrant expression of ErbB2 in salivary gland neoplasms, like MEC, indicates a distinctly aggressive behavior of these neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study

Sawant

Spadigam

Dhupar

et al. 2019

Heliyon

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Objectives– Routine histopathological grading for salivary gland mucoepidermoid carcinoma (MEC) have failed to prognosticate these tumors, resulting in poor post-surgical outcomes. In developing countries, the lack of technologically advanced infrastructure curtails, efficient treatment modalities. This study aimed at determining if MUC4β can characterize salivary gland MEC and serve as a practical and inexpensive method to prognosticate salivary gland MEC.Materials and methods– Fifteen cases of archived paraffin embedded tissue blocks of mucoepidermoid carcinomas were reassessed for histopathological grading using Healey's system, modified by Batsakis and Luna and immunohistochemically evaluated for expression of MUC4β. Statistical analysis (Kappa statistics and Spearman's rho correlation coefficient) was performed to assess inter-observer reproducibility and to correlate the expression of MUC4β with the histopathological grade of the tumor.ResultsMUC4β expression is related to tumor differentiation in an inverse relationship. Two cases of high grade MEC were the exception to this rule.ConclusionOur study revealed that MUC4β alone cannot serve as a reliable prognostic marker due to its divergent tumor suppressor and oncogenic pathway. The role of MUC4β needs further evaluation and research so as to potentiate therapeutics depending upon its context dependent function, as a cancer marker or an oncogenic factor.

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Section: Discussionmentioning

confidence: 99%

Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study

Sawant

Spadigam

Dhupar

et al. 2019

Heliyon

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“…The grade showed a correlation only with PCP4/PEP19. El-Attar and Deraz [ 27 ] reported that the higher the grade was, the higher the expression level of HER2, but this result suggests that the histology and malignancy of MECs may not correlate with the presence or absence of the expression of PCP4/PEP19 and HER2. The expression of EGFR did not correlate with clinicopathological factors in this study; however, Khiavi et al [ 28 ] reported that there was a statistically significant correlation between EGFR expression and the histopathological grading of MEC of the salivary glands.…”

Section: Discussionmentioning

confidence: 99%

PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland

Yoshimura

Higashi

Yamada

et al. 2021

Cancers

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Mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland carcinomas, but no effective treatment strategy has been established other than surgical resection. Purkinje cell protein (PCP) 4/peptide (PEP) 19 is a calmodulin-binding antiapoptotic peptide that is expressed and inhibits apoptosis in human breast cancer cells. Human epidermal growth factor receptor 2 (HER2) is an epidermal growth factor that has been implicated in the pathogenesis of many carcinomas, particularly breast and gastric carcinomas. In the present study, we performed immunohistochemical analyses of samples from 73 patients who underwent surgical resection for MEC of the salivary gland using antibodies against PCP4/PEP19 and HER2. PCP4/PEP19 expression was related to better prognosis, while HER2 expression was associated with worse prognosis. Patients that were PCP4/PEP19-positive and HER2-negative showed similar outcomes to PCP4/PEP19 and HER2 alone. Therefore, PCP4/PEP19 and HER2 are predicted to play important roles in the pathogenesis and progression of MEC.

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Expression of estrogen receptors (ER) and human epidermal growth factor receptor 2 (HER2) in mucoepidermoid carcinoma: Relationship to its grading

Cited by 2 publications

References 19 publications

Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study

Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study

PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland

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