VISA strains), with no totally vancomycin-resistant (VRSA) strains. All of phenotypic MRSA isolates, except of one, were positive for PBP2a. Conclusion:The study concludes that S. aureus is the most prevalent pathogen causing bacteremia in leukemia patients, with MRSA variety comprising the majority of these strains. Also, phenotypic method for MRSA detection can be performed using either of Methicillin, Oxacillin, or Cefoxitin with same results, with a nonsignificant statistical difference between the phenotypic method and the genotypic method-via the PBP2a detection.

Urinary Tract Infection (UTI) is second on the ranking of most common infection in community practice. It leads to significant morbidity and a high economic burden for treatment. Klebsiella pneumoniae accounts for 2 nd highest organism isolated from urine samples of UTI patients after Escherichia coli. The management of UTI is complicated by the increasing prevalence of antibiotic resistant strains of Klebsiella pneumonia. Therefore, knowledge of the antibiotic resistance patterns of the pathogen is important not only to provide an appropriate therapy, but also for the prevention of resistance amongst the microbe. OBJECTIVEThe present study was therefore undertaken to determine the antibiotic susceptibility pattern of Klebsiella pneumonia causing UTI in patients admitted to a tertiary care hospital. MATERIAL AND METHODSThe details of Klebsiella pneumonia grown in urine samples received in the Department of Microbiology, MOSC Medical College, were collected from the laboratory registers. These urine samples were then processed using standard methods and antibiotic susceptibility testing was done by Kirby Bauer's disc diffusion method. RESULTDuring the period of 4 months, 35 urine samples yielding Klebsiella pneumonia were processed. These strains showed 100% resistance to Ampicillin, around 70-85% resistance to first, second and third generation Cephalosporins. They showed maximum sensitivity to Imipenem (74.3%), followed by Colistin (77%), Amikacin (65.7%), Meropenem (65.7%) and Piperacillin-Tazobactam (65.7%). CONCLUSIONIn our study, the high rate of resistance to routinely prescribed drugs like Co-trimoxazole, Norfloxacin and Nitrofurantoin could be attributed to the frequent use of these antibiotics. Carbapenems (Imipenem or Meropenem) and Amikacin should be considered as reserved drugs, especially for nosocomial infections.

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