In the rat, chronic treatment with isoproterenol can cause a selective growth of the salivary glands to approximately five times their normal size within 17 days. This enlargement is principally due to mitotic proliferation and hypertrophy of the parenchymatous cells.

A calcareous subdeltoid bursitis can be regularly produced in the rat through calciphylactic challenge by Thorotrast after sensitization with dihydrotachysterol (DHT). This form of calciphylaxis is described merely as an experimental model of the disease without implying that a calciphylactic mechanism is necessarily responsible for structurally comparable lesions in man.Un subdeltoidic bursitis calcari pote esser producite regularmente in rattos per medio de un provocation calciphylactic per Thorotrast post sensibilisation con dihydrotachysterol (DHT). Iste forma de calciphylaxis es describite mermente como modello experimental del morbo, sin ulle intention de suggerer que un mechanism0 calciphylactic es necessarimente responsabile pro structuralmente comparabile lesiones in le homine.HE CALCIFYING bursitis of the shoulder joint (often referred to as T subacromial or subdeltoid bursitis, bursitis chronica calcarea, periarthritis humero-scapularis or muladie de Duplay) is not only of great practical importance but also poses many intriguing theoretical problems as regards the biochemical and mechanical factors that may be responsible for its development. Ever since its first description by Emanuel Simon Duplay in 1896, the etiology and pathogenesis of this common and often disabling condition has been the subject of intense investigation. Its clinical course and structural pathogenesis have been largely clarified, yet virtually nothing has been learned about its etiology. Various authors considered trauma, "wear and tear," overexertion, lack of activity, infection, allergy, "rheumatism," derangements in calcium metabolism, collagen disease, or other factors to be primarily responsible for this l e~i o n , l -~J~ but "in spite of many explanations as a working bksis, tld exact method by which calcium is deposited remains obscure."13

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