Background: Abnormal levels of serum uric acid (UA) causes major health problem due to itspivotal role in the etiology of many systemic diseases. Many research works in recent past haveshown elevated uric acid levels in diabetic subjects. Some reports indicate that uric acid elevationis related to diabetic complications, whereas a few claimed that uric acid elevation is also seen inpre-diabetic condition.The reason for this elevation of uric acid and a possible role of insulin inthis regard is obscure. Hence a study has been undertaken to assess the uric acid status in alloxandiabetic rats with an attempt to establish the possible cause for uric acid elevation. Methods:The studies were carried out on healthy male Wistar rats with a body weight of 150-180g. Therats were divided into two groups,normal group (Group-1) and alloxan diabetic group (Group-2)with six animals in each group. Induction of diabetes was done by administering a singleintraperitoneal injection of freshly prepared aqueous solution of Alloxan Monohydrate (150mg/Kg body weight) prepared in normal saline, to the overnight fasted rats. After the stipulatedperiod of 30 days, the animals (Group-1 and Group-2) were anesthetized using Isoflurane andsacrificed. They were dissected immediately and liver tissue was procured, blotted to removeblood stains, and placed in cold phosphate buffer saline (pH7.4). Blood samples were collectedusing heparin as anticoagulant.The uric acid levels in plasma, erythrocytes and in liver tissueas well as the levels of ADA in plasma and liver tissue were estimated. Results: A significant(p<0.001) rise in uric acid levels in plasma, erythrocytes and liver tissue as well as increasedlevels of ADA in plasma and liver tissue was observed in alloxan diabetic rats compared to normal control. Conclusion: The increased uric acid levels noticed in alloxan diabetic rats maybe due to increased catabolism of purines as evidenced by increased activity of ADA. Bangladesh Journal of Medical Science Vol.20(1) 2021 p.45-49
<p class="abstract"><strong>Background:</strong> Psoriasis, a chronic skin complication been considered in the recent years by dermatologists as a systemic disease with multi organ abnormalities. Dyslipidemia commonly observed in psoriasis patients may result in cardiovascular complications hence a prompt routine cardiovascular risk evaluation is essential in these patients. A study was designed to assess plasma lipid profile as well as cardiovascular risk markers in psoriasis patients to find out the relationship between cardiovascular risk indicators and psoriasis disease severity.</p><p class="abstract"><strong>Methods:</strong> Study consists of 200 subjects including 100 psoriatics. These psoriatics were sub-grouped based on their increasing PASI score into four groups.<strong></strong></p><p class="abstract"><strong>Results:</strong> The results indicate a significant elevation in lipid parameters and in cadiac risk ratio, atherogenic index of plasma as well as atherogenic coefficient in psoriatics as compared to normal controls. Further a parallel raise has seen in these lipid parameters and risk indicators based on their increasing PASI score.</p><p class="abstract"><strong>Conclusions:</strong> It can be stated from the study results that psoriatics are more affected group for cardiovascular complications and a proper evaluation of cardiovascular risk indicators in these patients is essential in preventing development of cardiovascular risk. Further the risk indicators atherogenic index of plasma and atherogenic coefficient are more promising in evaluating cardiovascular risk in psoriases patients.</p>
Objectives: The garlic and its principle sulfur compound, diallyl disulfide (DADS), have been claimed to have hypoglycemic activity and are helpful in achieving glycemic control in diabetes mellitus. The exact uric acid mechanism about the DADS controls on glucose level in diabetes mellitus is not clearly established though it is known that DADS does influence insulin action probably by improving insulin half-life. A study was undertaken to examine the role of DADS on purine metabolism and their metabolites in the diabetic condition and the probable connection of uric acid, xanthine oxidase and adenosine deaminase (ADA) enzymes in rat model. Materials and Methods: The induction of diabetes was done by alloxan and diabetic rats were treated with DADS for 30 days and compared with the standard hypoglycemic drug metformin. Purine metabolites alteration was measured by the activities of ADA, xanthine oxidase, and uric acid in the diabetes induced rats. Results: DADS which exhibits its strong action on glucose utilization in the liver tissues by regulating the purine metabolites in diabetic condition showing favorable changes in the levels of xanthine oxidase, ADA, and uric acid levels. Conclusion: This establish the possible effect of DADS on purine metabolites in alloxan diabetic liver tissues and to associate this action of DADS with metformin which is a common drug used for treating type-2 diabetes mellitus. DADS can be used as a therapeutic drug for glycemic control in diabetes mellitus.
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