Effect of Diallyl Disulphide on Diabetes Induced Dyslipidemia in Male Albino Rats

Sambu, Naveen Kumar; Kashinath, R T; Ambekar, Jeevan G

doi:10.7860/jcdr/2015/13374.5860

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…The chosen dose of DADS was selected based on preliminary experiment using 50, 75, and 100 mg/kg. The higher dose was found to be the best dose among these three doses in treating paw edema induced by carrageenan which was also in agreement with a previous report [13]. DADS and diclofenac were dissolved in 0.9% NaCl and gavaged to the mice for 5 consecutive days before carrageenan injection.…”

Section: Carrageenan-induced Paw Edemasupporting

confidence: 91%

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

Zhang

Shang

Tian

et al. 2020

Mediators of Inflammation

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Diallyl disulfide (DADS) is the major organosulfur constituent in garlic, with a variety of pharmacological activities including antioxidant and anti-inflammatory. Here, we examined the potential antiedematous impact of DADS- versus carrageenan-mediated paw edema in mice. Carrageenan injection potentiated an inflammatory reaction as presented by the elevated serological C-reactive protein (CRP) levels and transcription of tumor necrosis factor-alpha (TNF-α, Tnfα), interleukin-1 beta (IL-1β, Il1b), interleukin-2 (IL-2, Il2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase-2 (COX-2, Ptgs2), prostaglandin E2 (PGE2), monocyte chemoattractant protein-1 (MCP-1, Ccl1), nuclear factor kappa B (NF-κB), and myeloperoxidase (MPO) activity, while interleukin-10 (IL-10) was declined in the injured paw tissue. Additionally, carrageenan elevated lipid peroxidation in terms of malondialdehyde (MDA) and decreased glutathione content (GSH). Remarkably, DADS was found to inhibit the inflammatory signaling, suppressed the developed oxidative damage, and protected the histopathological alterations in the inflamed paw tissue in response to carrageenan injection. Our findings suggest that DADS could be used as an alternative therapy used to alleviate the pathophysiological changes associated with the genesis of paw edema through its potent anti-inflammatory and antioxidant impacts.

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Section: Carrageenan-induced Paw Edemasupporting

confidence: 91%

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

Zhang

Shang

Tian

et al. 2020

Mediators of Inflammation

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“…Although the pathogenesis of T2DM-induced renal damage is multiple and complicated, dyslipidemia and subsequent lipotoxicity play important roles in this process and accelerate kidney injury. Dyslipidemia, defined as abnormal lipid profiles characterized by increased plasma and tissue levels of TG, TC, and LDL [ 21 ], is a major complication associated with high morbidity and mortality in diabetics [ 25 ]. Diabetes-related dyslipidemia is responsible for lipid accumulation in the kidney, which leads to insulin resistance, inflammation, and oxidative stress [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet‐Streptozotocin‐Induced Diabetic Sprague Dawley Rats

Liu

Song

Teng

et al. 2016

Oxidative Medicine and Cellular Longevity

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Cordyceps militaris has long been used as a crude drug and folk tonic food in East Asia. The present study aims to evaluate the antidiabetic and antinephritic effects of the aqueous extract of the Cordyceps militaris fruit body (CM) in diet-streptozotocin- (STZ-) induced diabetic rats. During four weeks of continuous oral administration of CM at doses of 0.5, 1.0, and 2.0 g/kg and metformin at 100 mg/kg, the fasting blood glucose and bodyweight of each rat were monitored. Hypoglycemic effects of CM on diabetic rats were indicated by decreases in plasma glucose, food and water intake, and urine output. The hypolipidemic activity of CM was confirmed by the normalization of total cholesterol, triglycerides, and low- and high-density lipoprotein cholesterol in diabetic rats. Inhibitory effects on albuminuria, creatinine, urea nitrogen, and n-acetyl-β-d-glucosaminidase verified CM's renal protective activity in diabetic rats. Furthermore, CM exerted beneficial modulation of inflammatory factors and oxidative enzymes. Compared with untreated diabetic rats, CM decreased the expression of phosphor-AKT and phosphor-GSK-3β in the kidneys. Altogether, via attenuating oxidative stress, CM displayed antidiabetic and antinephritic activities in diet-STZ-induced diabetic rats.

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“…Fe-S clusters are vitally important for the origin of life, particularly acetyl-CoA, RNA, and DNA (Fuss et al, 2015 ). Organosulfur compounds (Figure 5 ) usually present in onion, garlic, and Chinese chive, which may benefit a certain group of the population because they appear to combat oxidative stress associated age-related diseases such as cardiovascular disease (Lu et al, 2015 ; Seki and Hosono, 2015 ; Wang et al, 2015 ), diabetes (Akash et al, 2014 ; Sambu et al, 2015 ), obesity (Lai et al, 2014 ), and neuroinflammation (Colín-González et al, 2015 ; Wen and Zhu, 2015 ). Organosulfur compounds such as S -allylcysteine has anti-apoptotic, anti-oxidation, and anti-inflammation (Colín-González et al, 2015 ) in addition to alleviating several diseases (Kodai et al, 2015 ).…”

Section: Role Of Antioxidants In the Prevention Of Age-related Diseasmentioning

confidence: 99%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

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Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.

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Effect of Diallyl Disulphide on Diabetes Induced Dyslipidemia in Male Albino Rats

Cited by 12 publications

References 13 publications

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice

Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet‐Streptozotocin‐Induced Diabetic Sprague Dawley Rats

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

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