Alterations in plasma lipid profile and cardiovascular risk indicators in clinically sub-grouped psoriasis

Abstract

<p class="abstract"><strong>Background:</strong> Psoriasis, a chronic skin complication been considered in the recent years by dermatologists as a systemic disease with multi organ abnormalities. Dyslipidemia commonly observed in psoriasis patients may result in cardiovascular complications hence a prompt routine cardiovascular risk evaluation is essential in these patients. A study was designed to assess plasma lipid profile as well as cardiovascular risk markers in psoriasis patients to find out the relationship between cardiovascular risk indicators and psoriasis disease severity.</p><p class="abstract"><strong>Methods:</strong> Study consists of 200 subjects including 100 psoriatics. These psoriatics were sub-grouped based on their increasing PASI score into four groups.<strong></strong></p><p class="abstract"><strong>Results:</strong> The results indicate a significant elevation in lipid parameters and in cadiac risk ratio, atherogenic index of plasma as well as atherogenic coefficient in psoriatics as compared to normal controls. Further a parallel raise has seen in these lipid parameters and risk indicators based on their increasing PASI score.</p><p class="abstract"><strong>Conclusions:</strong> It can be stated from the study results that psoriatics are more affected group for cardiovascular complications and a proper evaluation of cardiovascular risk indicators in these patients is essential in preventing development of cardiovascular risk. Further the risk indicators atherogenic index of plasma and atherogenic coefficient are more promising in evaluating cardiovascular risk in psoriases patients.</p>

The relationship between obesity, cardiometabolic disorders and disease activity in psoriatic arthritis patients: data from the Russian register

“…У большинства больных нашей когорты -ограниченный бляшечный Пс (BSA<3%) и не выявлено корреляции тяжести Пс с активностью ПсА, ИМТ и наличием коморбидных заболеваний. Однако данные других исследований демонстрируют ассоциацию тяжести Пс с такими показателями, как активность ПсА, ИМТ, и распространенностью сопутствующих заболеваний, особенно сердечно-сосудистых [33,34]. Наличие тяжелых форм Пс (локализация кожных поражений в 3 различных областях, обширные кожные поражения) является предиктором развития ПсА наряду с высоким ИМТ, женским полом, терапией глюкокортикоидами, поражением ногтевых пластин, наследственностью по Пс и ПсА, беременностью, курением у женщин, увеитом [35][36][37].…”