No abstract
A multileaf collimator for electrons (eMLC) has been designed that fulfils the technical requirements for providing advanced irradiation techniques with electrons. In the present work, the basic design parameters of leaf material, leaf height, leaf width and number of leaves as well as leaf overtravel and leaf shape were determined such that an eMLC with motorized leaves can be manufactured by a company specialized in MLC technology. For this purpose, a manually driven eMLC with variable source-to-collimator distance (SCD) was used to evaluate the chosen leaf specification and investigate the impact of the SCD on the off-axis dose distribution. In order to select the final SCD of the eMLC, a compromise had to be found between maximum field size, minimum beam penumbra and necessary distance between eMLC and isocentre to eliminate patient realignments during gantry rotation. As a result, the eMLC is placed according to the target position at 72 and 84 cm SCD, respectively. This feature will be achieved by interchangeable distance holders. At these SCDs, the corresponding maximum field sizes at 100 cm source-to-isocentre distance are 20 x 20 cm and 17 x 17 cm, respectively. Finally, the off-axis dose distribution at the maximum opening of the eMLC was improved by fine-tuning the settings of the accelerator jaws and introducing trimmer bars above the eMLC. Following this optimization, a prototype eMLC consisting of 2 x 24 computer-controlled brass leaves is manufactured by 3D Line Medical Systems.
A method is introduced for the evaluation of x-ray spectra from x-ray machines operating in the range 50-100 kVp using a cadmium telluride (CdTe) detector with low detection efficiency. The pulse height distribution obtained with this kind of detector does not represent the true photon spectra owing to the presence of K-escape, Compton scattering, etc.; these effects were evaluated using a Monte Carlo method. A stripping procedure is described for implementation on a Univac 1100/82 computer. The validity of our method was finally tested by comparison with experimental results obtained with a Ge detector and with data from the literature; the results are in good agreement with published data.
We propose a multidimensional clinical evaluation to select those mCRPC subjects suitable to receive the maximum benefit from Ra treatment.
The Depth of Interaction (Dol) detection is crucial in many medical imaging applications such as small ring PET and high resolution SPECT. In this work we investigate the possibility to discriminate the Dol using continuous crystals. A LaBr3(Ce) crystal has been used in the detection system for its intrinsic high light yield, that especially at low energies (e. g. 140 keY) reduces considerably the statistical uncertainties increasing the Dol discrimination power. The innovative suggestion of this work is the use of spectrometric observables to discriminate events on top and bottom of the crystal, under the hypothesis that scintillation light distributions can be parameterized by a gaussian model. The spread of the light cone (sigma) is proportional to the Dol simply by geometrical considerations, but under the gaussian hypothesis relations between the spectrometric variables (maximum high I and integral of the distribution N) and the Dol become a straightforward consequence. Two methods are proposed and discussed: a linear treatment of the light distribution and a non linear (quadratic) manipulation of it. The expected correlations between the spectrometric variables (N and I), according to the gaussian model, are checked using a specific Monte Carlo simulation of the experimental apparatus. Those are then compared with experimental data obtained irradiating the LaBr3:Ce crystal with a Tc-99m collimated source. A close agreement between experimental data and MC is verified. Finally, a preliminary test on experimental data has been performed irradiating the crystal with a Co-57 source, in order to investigate the strong dependence of the non linear manipulation of the light distribution to the DoI
Recently scintillators with very high light yield and photodetectors with high quantum efficiency have been opening a new way to realize gamma cameras with superior performances based on continuous crystals. Pixilated imagers have a spatial resolution limited by pixel size, in contrast with continuous scintillation crystals, where spatial resolution is a statistical function depending on light distribution spread and on generated photoelectrons from scintillation light flash. Continuous LaBr3:Ce crystal, with a light yield almost two times higher than NaI:TI ones and a lower intrinsic energy resolution, could be the best candidate to carry out a gamma imaging with sub-millimeter spatial resolution and very good energy resolution. Unfortunately standard Anger algorithm produces an intrinsic position nonlinearity affecting spatial resolution for small size continuous crystal. In this work we propose a new method to calculate the position mean value by squaring the 2D collected charge distribution on a multi-anodes photomultiplier tube (MA-PMT). In this study we take into account four different detector configurations: three sample of LaBr3:Ce scintillation crystals, 49mm x 49mm area, a couple of 4.0 with different surface treatment and a single 10 mm thick, with 3 mm glass window. Moreover a forth one with 5.0mm thickness which was integral assembled with an Hamamatsu H8500. We applied the new position algorithm to simulated data, obtained by Geant4 code and afterwards to the experimental data obtained scanning the different detectors with 0.4 mm 0 collimated Tc 99m point source, at 1.5 mm step. The results obtained with the new algorithm show an improvement in position linearity and in spatial resolution of about a factor two. The best values in terms of spatial resolution were 0.9 mm, 1.1 mm and 1.8 mm for integral assembled, 4.0 mm thick and 10 mm thick LaBr3:Ce crystal respectively. These results demonstrate the potential of LaBr
The commonly used gamma probes are easy to use but also give rough information when employed in radioisotope-guided surgery. When images are required for exact localization, a gamma camera as well as a probe have to be used. Position-sensitive photomultipliers have contemporaneously allowed high-resolution scintigraphy and miniaturization of gamma cameras. We have assembled a miniature gamma camera with a 1-square-inch field of view and an intrinsic resolution of about 1 mm. When the minicamera is collimated with a large-holed, highly sensitive collimator, it acquires a spatial resolution of 3 mm. This prototype has been tested in the detection of difficult-to-image breast cancer sentinel nodes. Five nodes that had not been found with the usual technique of an Anger camera plus conventional probe were checked with the miniature camera that we named imaging probe: it actually is small enough to be used as a probe and large enough to give an image. One of the five nodes was found and imaged. It was small, disease-free, close to the tumor and probably hidden by the Compton halo around the peritumoral injection site. Our pilot study shows that the imaging probe, although still a prototype, has certain advantages over conventional methods when lymph node localization is required during surgery.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.