Eighty-three south Indian patients with psoriasis vulgaris were studied for HLA antigen frequencies and compared with 77 controls studied simultaneously. HLA Bw57, a split of B17 was found elevated in the patients. The two sexes differed in their age-at-onset curves: females had a preponderance to early onset of the disease, while the males had late onset. Among these patients, major group 3, a Western Brachycephal Armenoid group, revealed the highest risk for B17 & Bw57 but not major group 2, a Mediterranean one.
This paper describes the distribution of thymus-derived lymphocytes in the spleen of the lizard, Calotes versicolor. Our studies reveal the existence of red and white pulp in the spleen. The red pulp consists of collagenous fibrous septae containing lymphocytes, erythrocytes and sinuses. The white pulp is an area enclosed by fibrous septae, containing lymphocytes, reticular cells and arterioles. The region around the arteriole in the white pulp was depleted of lymphocytes either one month after adult thymectomy or after anti-thymocyte serum treatment. The repopulation of this region was observed in sham-thymectomized controls, but not in thymectomized lizards. Therefore, this peri-arteriolar region may be designated as a thymus-dependent area, as described previously in higher vertebrates. The significance of these findings is discussed in relation to the phylogeny of the immune system.
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