Association of pulmonary tuberculosis and HLA in South India

Brahmajothi, V.; Pitchappan, R. M.; Kakkanaiah, Vellalore N.; Sashidhar, M.; Rajaram, Kanchana; Ramu, Shivabalan Kathavarayan; Palanimurugan, K.; Paramasivan, C. N.; Prabhakar, R

doi:10.1016/0041-3879(91)90039-u

Cited by 133 publications

(56 citation statements)

References 24 publications

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“…111 Thus, several studies of HLA association with pulmonary tuberculosis have been carried out in Chinese, 111,112 Korean, 113 Indonesian, 114 Indian 115-121 and Russian patients. 122 Of the numerous Indian studies on HLA association with pulmonary tuberculosis, the earlier studies focussed on association of HLA Class I antigens 115,116 and later in family studies in North India 118,120 and South India 117,121 that focussed on HLA Class II antigens. An increased frequency of HLA-DR2 and DQ1 was shown to be associated with the susceptibility to pulmonary tuberculosis in Indian population.…”

Section: Hla and Mycobacterium Tuberculosis Infectionmentioning

confidence: 99%

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Major histocompatibility complex and its importance towards controlling infection

Longjam

Das

2017

Asian J Med Sci

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It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response during infection could be under genetic control. The Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) system is the most intensively studied of all genetic systems because of its influence to many important traits, including resistance to infectious diseases, autoimmunity and immunological self or nonself compatibility. This is understandable in the light of the evolutionary pressure so that we are equipped to face the multitude of infectious challenges. Infectious diseases are a major selective pressure;and genes involved in the immune response are the most numerous and diverse in the human genome; reflecting the evolutionary advantages of a diverse immunological response to a wide range of infectious pathogens.Asian Journal of Medical Sciences Vol.8(2) 2017 1-13

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Section: Hla and Mycobacterium Tuberculosis Infectionmentioning

confidence: 99%

“…Molecular study has revealed that the allele DRB1*1501 of HLA-DR2 was higher compared with DRB1*1502 in North Indian patients. [117][118][119][120][121]123 Moreover, the TAP2 has been found associated with active tuberculosis along with HLA-DR2 in North Indian pulmonary tuberculosis patients.…”

Section: Hla and Mycobacterium Tuberculosis Infectionmentioning

confidence: 99%

Major histocompatibility complex and its importance towards controlling infection

Longjam

Das

2017

Asian J Med Sci

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“…Several candidate genes have been investigated in different populations, some of them presenting variants showing strong association with the disease, such as HLA genes, Interferon Gamma (IFNG), Natural Resistance Associated Macrophage Protein 1 (NRAMP1 or SCL11A1), TLR2 and the Vitamin D Receptor (VDR). 23,[26][27][28][29][30][31][32][33][34][35][36][37][38] Cutaneous tuberculosis is a rare form of extra pulmonary disease that affects 1 to 4% of the total cases of TB. 39,40 Cutaneous TB occurs more often in children, intravenous drug users and individuals under immunosuppressive therapy, as well as individuals affected by HIV/AIDS, diabetes mellitus, cancer and end-stage renal disease.…”

Section: Cutaneous Tuberculosis and Other Mycobacteriosismentioning

confidence: 99%

Genetic risk factors for human susceptibility to infections of relevance in dermatology

Sardinha

Tarlé

Fava

et al. 2011

An. Bras. Dermatol.

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BACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectious diseases in different stages of understanding of their molecular basis. In this review, we summarize the main advances towards dissecting the genetic component controlling human susceptibility to infectious diseases of interest in dermatology. Widely investigated diseases such as leprosy and leishmaniasis are discussed from the genetic perspective of both host and pathogen. Others, such as rare mycobacterioses, fungal infections and syphilis, are presented as good opportunities for research in the field of genetics of infection. Keywords: Dermatology; Infection; Polymorphism, genetic Resumo: INTRODUÇÃO: Durante a era pré-microbiológica, era comum a visão de que doenças, hoje sabidamente infecciosas, eram hereditárias. Com a descoberta dos microorganismos e seu papel na patogênese de diversas patologias, chegou-se a propor que a exposição ao patógeno era condição suficiente para explicar infecção. Hoje, está claro que infecção é o resultado de uma complexa interação entre patógeno e hospedeiro, dependendo portanto, em última análise, do make-up genético de ambos os organismos. A dermatologia oferece diversos exemplos de doenças infecciosas em diferentes graus de entendimento de suas bases moleculares. Nesta revisão, resumimos os principais avanços na direção da dissecção do componente genético controlando suscetibilidade do ser humano a doenças infecciosas de importância na dermatologia. Doenças amplamente estudadas, como a hanseníase e a leishmaniose, são discutidas sob o ponto de vista da genética tanto do hospedeiro quanto do patógeno. Outras, como micobacterioses raras, micoses e sífilis, são apresentadas como boas oportunidades para pesquisa na área de genética de infecção.

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“…Much of the variation in HLA genes between populations is thought to result from different selection pressures, such as infectious diseases. Some of the first studies to show association with TB were with HLA, both with class I B8 (18) and class II alleles; with DR2 associated with pulmonary TB in India (18,19) and Mexico (20), and with both tuberculoid and lepromatous forms of leprosy in Brazil (21). A two-stage study in Cambodia found an association between HLA-DQB1 and pulmonary TB (22).…”

Section: Human Leukocyte Antigen (Hla) Genesmentioning

confidence: 99%

Human Genetic Susceptibility to Tuberculosis and Other Mycobacterial Diseases

Hoal

2002

IUBMB Life

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SummaryThe existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease.

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Association of pulmonary tuberculosis and HLA in South India

Cited by 133 publications

References 24 publications

Major histocompatibility complex and its importance towards controlling infection

Major histocompatibility complex and its importance towards controlling infection

Genetic risk factors for human susceptibility to infections of relevance in dermatology

Human Genetic Susceptibility to Tuberculosis and Other Mycobacterial Diseases

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