2011
DOI: 10.1590/s0365-05962011000400013
|View full text |Cite
|
Sign up to set email alerts
|

Genetic risk factors for human susceptibility to infections of relevance in dermatology

Abstract: BACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
5
0
1

Year Published

2014
2014
2021
2021

Publication Types

Select...
5
1
1

Relationship

0
7

Authors

Journals

citations
Cited by 8 publications
(7 citation statements)
references
References 78 publications
0
5
0
1
Order By: Relevance
“…A higher susceptibility to these diseases in males, apart from possible differences in exposure and in risk factors, could be related to the influence of androgen hormones in their pathogenicity, as suggested in previous studies. This could also partially explain a higher occurrence in adults [ 13 , 14 ]. Furthermore, children and young adults with paracoccidioidomycosis may be more likely to present the acute/subacute form of the disease, which affects mainly the lymphohematopoietic system, with a lower involvement of mucocutaneous regions [ 15 , 16 ].…”
Section: Discussionmentioning
confidence: 99%
“…A higher susceptibility to these diseases in males, apart from possible differences in exposure and in risk factors, could be related to the influence of androgen hormones in their pathogenicity, as suggested in previous studies. This could also partially explain a higher occurrence in adults [ 13 , 14 ]. Furthermore, children and young adults with paracoccidioidomycosis may be more likely to present the acute/subacute form of the disease, which affects mainly the lymphohematopoietic system, with a lower involvement of mucocutaneous regions [ 15 , 16 ].…”
Section: Discussionmentioning
confidence: 99%
“…Today, it is clear that the infection is the result of a complex interaction between pathogen and host. 7 The patient presented lesions with no regional lymphadenopathy and no evidence of systemic involvement. Also, Histoplasma capsulatum was isolated and identified.…”
Section: Discussionmentioning
confidence: 93%
“…Now, challenge for biologists is to identify genetic components that predispose individuals to fungal infection. The study of genes will help to understand the relationship between genetic polymorphism and the cellular phenotype of host and pathogen ( Sardinha et al, 2011 ). Recent research outcomes aided by genomic sequencing point toward an interesting link between genetic predisposition to fungal infections and human ancestry.…”
Section: Introductionmentioning
confidence: 99%
“…Single nucleotide polymorphism (SNP) in key immune genes plays an important role in fungal infection affecting particular ancestral populations ( Hughes et al, 2008 ; Dominguez-Andres and Netea, 2019 ). Thus, with the availability of genetic information, we can study the mechanism behind host defense against the pathogen, susceptibility toward infection ( Sardinha et al, 2011 ), and also have an idea of how the pathogens are evolving and trying to adapt to their host environment through host-pathogen interactions.…”
Section: Introductionmentioning
confidence: 99%