Objective To evaluate the diagnosis, outcome and final and lymph node status for cancer-specific survival. Multivariate analysis showed vascular invasion to be pathology of radical prostatectomy for prostate cancer performed by urologists in a clinic where six urologists the most important prognostic variable, followed by capsular perforation, positive margins of resection and perform a total of 50 radical prostatectomies a year, using radical prostatectomy specimens processed poorly differentiated carcinoma. The overall results for the evaluated variables were comparable to the results routinely. Patients and methods Radical prostatectomy was perfrom centres with greater experience. Conclusions The outcome of treatment in this small formed in 273 patients who were followed prospectively. The radical prostatectomy specimens were clinic was similar to that from larger clinics with more experience. The routine evaluation of the radical prosevaluated for pathological stage, histological grade, capsular perforation, positive lateral and apical martatectomy specimens identified pathological variables which were important prognostic factors, with vascugins of resection, seminal vesicle invasion, perineural invasion and vascular invasion; the lymph node status lar invasion, capsular perforation, positive margins of resection and poorly differentiated carcinoma being was also determined. The relationship between these variables and clinical progression, local recurrence, the most significant. The extent of vascular invasion should be part of the routine evaluation of radical distant metastases, biochemical progression, overall survival and cancer-specific survival was assessed.prostatectomy specimens.
Objectives To determine whether the ratio of free to Tandem E assays. Compared with the total serum PSA level, the F/T ratio improved the specificity signifitotal (F/T) prostate-specific antigen (PSA) can diÂer-entiate between men with prostate carcinoma or cantly only in those men with a total PSA of Á7 ng/mL. Using the information given by the total benign conditions in a screened population. Subjects and methods Total and free serum PSA (measand free PSA values, a maximum sensitivity of 75% at a specificity of 74% was obtained for the whole ured using Delfia PSA assays, Abbott IMx and Hybritech Tandem E methods) were determined retro-PSA range from 4 to 10 ng/mL; the maximum sensitivity was 79% with a specificity of 71%. spectively in 1726 men aged 55-77 years, in whom 67 prostate carcinomas were detected by screening Conclusion The optimal mathematical combination of free and total serum PSA improves the specificity of with a digital rectal examination, transrectal ultrasonography, and total serum PSA level. Predictors for a total serum PSA level in detecting prostate carcinoma more than the does the F/T PSA ratio. positive biopsy result were estimated as a function of total PSA, free PSA and the combination of both.
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