Tumour control according to pathological variables in patients treated by radical prostatectomy for clinically localized carcinoma of the prostate

Abstract

Objective To evaluate the diagnosis, outcome and final and lymph node status for cancer-specific survival. Multivariate analysis showed vascular invasion to be pathology of radical prostatectomy for prostate cancer performed by urologists in a clinic where six urologists the most important prognostic variable, followed by capsular perforation, positive margins of resection and perform a total of 50 radical prostatectomies a year, using radical prostatectomy specimens processed poorly differentiated carcinoma. The overall results for the evaluated variables were comparable to the results routinely. Patients and methods Radical prostatectomy was perfrom centres with greater experience. Conclusions The outcome of treatment in this small formed in 273 patients who were followed prospectively. The radical prostatectomy specimens were clinic was similar to that from larger clinics with more experience. The routine evaluation of the radical prosevaluated for pathological stage, histological grade, capsular perforation, positive lateral and apical martatectomy specimens identified pathological variables which were important prognostic factors, with vascugins of resection, seminal vesicle invasion, perineural invasion and vascular invasion; the lymph node status lar invasion, capsular perforation, positive margins of resection and poorly differentiated carcinoma being was also determined. The relationship between these variables and clinical progression, local recurrence, the most significant. The extent of vascular invasion should be part of the routine evaluation of radical distant metastases, biochemical progression, overall survival and cancer-specific survival was assessed.prostatectomy specimens.

Does perineural invasion in a radical prostatectomy specimen predict biochemical recurrence in men with prostate cancer?

“…Although a number of studies have found that PNI predicts BCR on univariable analysis, [7][8][9][10][11][12][13][14][15] only two studies have reported PNI as a significant predictor on multivariable analysis. 8,13 Both of these studies examined relatively small cohorts of fewer than 250 participants.…”

Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens

“…In two studies [40,108] the data are similar in that the progression-free probability at 5 years following radical prostatectomy ranges from 81% to 83% for margin-negative disease, with a probability of 58 Á/64% for margin-positive disease. In the study by Van Den Ouden et al [109], margin negativity was associated with a 61% progression-free interval at 5 years, with a corresponding value of 28% for positive margins. There should be some indication (e.g.…”

Prognostic Factors for Failure after Prostatectomy

“…The degree of proliferation is considered by some to be a marker of aggressiveness and it's mediators such as vascular endothelial growth factor (VEGF) and it's receptors such as VEGFR 1-3 a r e t a r g e t s o f t h e r a p y i n m a n y cancers. In prostate cancer, it appears in some studies that high micro vascular density (MVD) is associated with progression, in some cases strongly so (105)(106)(107), but just as many other studies show that when considered with multiple factors, it is not predictive on multivariate analysis. (108)(109)(110)(111).…”