Prognostic Factors for Failure after Prostatectomy

Swanson, Gregory P.; Basler, Joseph W.

doi:10.7150/jca.2.1

Cited by 53 publications

(43 citation statements)

References 136 publications

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“…Higher Gleason score, distant metastasis and shorter PSADT are all known adverse prognostic factors of PCa. 21 Here, we have shown that VM is also an adverse prognostic factor of PCa. Furthermore, multivariate analysis indicated that in addition to VM, higher Gleason score and distant metastasis were also adverse predictors for OS and DFS.…”

Section: Discussionmentioning

confidence: 90%

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Liu

Yang

Meng

et al. 2012

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 90%

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Liu

Yang

Meng

et al. 2012

Cancer Biology & Therapy

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“…2 Despite curative-intent surgery, a proportion of patients will develop disease recurrence, particularly those harboring adverse pathologic features. 3 Randomized trials have shown that adjuvant radiation therapy (ART) in these patients reduces the risk of biochemical failure, increasing metastases-free survival and potentially overall survival. [4][5][6] Furthermore, a significant proportion of patients presenting with rising serum prostate-specific antigen (PSA) after prostatectomy can be successfully salvaged with radiation therapy (SRT).…”

Section: Introductionmentioning

confidence: 99%

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes

Berlin

Cho

Kong

et al. 2015

Practical Radiation Oncology

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“…Some studies have shown that in case of seminal vesicle or lymph node involvement, margin status may not be independently predictive due to the overwhelming risk of disease recurrence associated with those two factors (20,21). There is evidence that factors such as the location, extent and number of positive margins may have an impact on disease recurrence (13,22).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Biochemical Failure Following Radical Prostatectomy With Positive Surgical Margins

Mofid

Kakroodi²,

Simforoosh

et al. 2015

Rep Radiother Oncol

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Background: Radical prostatectomy is an established treatment modality for prostate cancer. Following radical prostatectomy, patients with positive surgical margins have increased risk of biochemical, and subsequently, clinical relapse. However, not all patients with positive margins will suffer disease recurrence. The aim of this study was to assess the factors that might predict the higher risk of disease recurrence in prostate cancer patients with positive surgical margins. Objectives: The aim of this study was to assess the factors that might predict the higher risk of disease recurrence in prostate cancer patients with positive surgical margins. Patients and Methods: From March 2009 till October 2013, seventy seven patients who had pathologically proven positive surgical margins after radical prostatectomy were followed and serum PSA levels were measured every three months. In case of biochemical failure, they were treated with salvage radiotherapy. Apart from pre-op and serial post-op PSA levels, number of positive margins based on anatomical classification of prostate, lymphovascular and perineural invasion, Gleason score and T-stage of the cancer were documented accurately. Results: Fifty one patients (66.2%) had a single positive margin, while 26 (33.8%) had multiple positive margins. Among all 77 patients, 67 (87%) had biochemical failure. Cox regression analysis showed that among various parameters, only pre-op PSA>20ng/ml and having more than one positive margins were able to predict the likelihood of biochemical failure in the patients; while Gleason score, perineural invasion and lymphovascular invasion did not seem to have an important role in this regard. Conclusions: Among patients with positive surgical margins after radical prostatectomy, those with pre-op PSA>20ng/ml or more than one positive margins are at greater risk of biochemical or/and clinical failure. In these patients, starting salvage radiotherapy after surgery might be considered as a logic option.

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Prognostic Factors for Failure after Prostatectomy

Cited by 53 publications

References 136 publications

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes

Predictors of Biochemical Failure Following Radical Prostatectomy With Positive Surgical Margins

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