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These studies point towards an important role of immune modifying genes, such as HLA, in influencing susceptibility to juvenile-onset AITD.

Alterations in at least one of the components of the p16/cyclin D1/pRb pathway in majority of the 70 patients analysed herein, and concomitant alterations in all the three proteins in 19 patients (35%) underscore the critical role of this pathway in esophageal tumourigenesis. The results of the present study taken together with our previous findings on p16 and pRb alterations in ESCCs suggest that these alterations are not mutually exclusive and may cooperatively provide greater tumour growth advantage. The prognostic significance of alterations in the expression of these components cyclin D1, p16, and pRb remains to be established in a larger cohort.

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Refences1. Bruhat MA, Pouly JL. Endoscopic treatment of ectopic pregnancies. Curr Opin Obstet Gynecol 1993; 5: 260-266. 2. Silva PD. Alaparoscopic approach can be applied to most cases of ectopic pregnancy. Obstet Gynecol 1988; 7 2 944-947. 3. Parker JL, Thompson DJ. Persistent ectopic pregnancy after conservative management. Successful treatment with single-dose intramuscular methotrexate. Aust NZ J Obstet Gynaecol 1994; 3 4 1: 99. Seifer BD, Gutman JN, Grant WD, Kamps CA, DeCherney AH. Comparison of persistent ectopic pregnancy after laparoscopic salpingostomy versus salpingostomy at laparotomy for ectopic pregnancy. EDITORIAL COMMENTP. We accepted this paper to remind even those readers who are obstetricians and/or gynaecologists that ectopic prPgnancy may elude diagnosis unless the possibility is considered in any women during her reproduefive years who has abdominal pain, especialb when associated with anaemia and disordered menstruation.The presence of pathology in another system can be a dktracter from prompt diagnosis of ruptumd ectopic pregnancy as shown by these 2 cases.