Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications

Mathew, Robin; Khanna, R.; Kumar, Rajesh; Mathur, Meera; Shukla, Nootan Kumar; Ralhan, Ranju

doi:10.1016/s0361-090x(02)00035-1

Cited by 43 publications

(34 citation statements)

References 25 publications

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“…In tumour tissues, consistent with its epithelial-specific expression, MMP-10 is predominantly expressed in the tumour mass rather than the surrounding stromal fibroblasts, unlike several other MMPs that are predominantly found in tumour stroma (Kerkela et al, 2001;Impola et al, 2004). Of note, MMP-10 expression is associated with malignant aggressiveness in various cancers (Mathew et al, 2002;Cho et al, 2004;Gill et al, 2004;Aung et al, 2006;Miyata et al, 2007). Mechanistically, MMP-10 is considered to be involved in the remodelling of the extracellular matrix associated with growth and expansion of the neoplastic cell mass rather than metastatic potential (Kerkela et al, 2001;Cho et al, 2004;Impola et al, 2004).…”

Section: Introductionmentioning

confidence: 78%

Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation of class IIa HDACs

et al. 2009

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Section: Introductionmentioning

confidence: 78%

Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation of class IIa HDACs

et al. 2009

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“…Our data also indicate that MMP-10 expression profiling may be of prognostic significance. Interestingly, MMP-10 overexpression has also been observed in squamous cell carcinomas of the head and neck (Muller et al, 1991;O-Charoenrat et al, 2001), oral cavity (Impola et al, 2004) and esophagus (Mathew et al, 2002). These tumor types harbor frequent chromosome 3q26 and PRKCI amplification (Pimkhaokham et al, 2000;Imoto et al, 2001;Snaddon et al, 2001;Osada and Takahashi, 2002).…”

Section: Discussionmentioning

confidence: 98%

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

et al. 2008

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“…This may explain why we found a modest increase in MMP10 in the malignant samples, but were unable to determine which Gleason grade was responsible for the increase. Other studies have observed MMP10 upregulation in oesophageal carcinomas (Mathew et al, 2002), recurrent lung carcinomas (Cho et al, 2004) and in gliomas (Thorns et al, 2003), where they predict a more malignant phenotype. Similarly, Van Themsche et al (2004) found that induction of MMP10 expression in lymphoma cell lines promoted their malignant phenotype.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 88%

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

et al. 2005

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Extracellular proteases of the matrix metalloproteinase (MMP) and serine protease families participate in many aspects of tumour growth and metastasis. Using quantitative real-time RT -PCR analysis, we have undertaken a comprehensive survey of the expression of these enzymes and of their natural inhibitors in 44 cases of human prostate cancer and 23 benign prostate specimens. We found increased expression of MMP10, 15, 24, 25 and 26, urokinase plasminogen activator-receptor (uPAR) and plasminogen activator inhibitor-1 (PAI1), and the newly characterised serine proteases hepsin and matriptase-1 (MTSP1) in malignant tissue compared to benign prostate tissue. In contrast, there was significantly decreased expression of MMP2 and MMP23, maspin, and the protease inhibitors tissue inhibitor of metalloproteinase 3 (TIMP3), TIMP4 and RECK (reversion-inducing cysteine-rich protein with Kazal motifs) in the cancer specimens. The expression of MMP15 and MMP26 correlated positively with Gleason score, whereas TIMP3, TIMP4 and RECK expression correlated negatively with Gleason score. The cellular localisation of the expression of the deregulated genes was evaluated using primary malignant epithelial and stromal cell cultures derived from radical prostatectomy specimens. MMP10 and 25, hepsin, MTSP1 and maspin showed predominantly epithelial expression, whereas TIMP 3 and 4, RECK, MMP2 and 23, uPAR and PAI1 were produced primarily by stromal cells. These data provide the first comprehensive and quantitative analysis of the expression and localisation of MMPs and their inhibitors in human prostate cancer, leading to the identification of several genes involved in proteolysis as potential prognostic indicators, in particular hepsin, MTSP1, MMP26, PAI1, uPAR, MMP15, TIMP3, TIMP4, maspin and RECK.

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Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications

Cited by 43 publications

References 25 publications

Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation of class IIa HDACs

Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation of class IIa HDACs

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

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