Salah satu penyakit yang saat ini menjadi prioritas oleh dunia kesehatan secara global atau dunia adalah hipertensi. Prevalensi penderita hipertensi di Puskesmas Labruk Kidul Kabupaten Lumajang sebesar 43,91%. Penderita hipertensi tidak dapat mengontrol tekanan darahnya karena beberapa penderita hipertensi sebelumnya kurang memiliki edukasi tentang hipertensi. Hal ini dikarenakan media yang hanya berupa leaflet yang monoton dan tidak adanya media poster yang menarik tentang hipertensi, sehingga tidak efektif dalam mengatasi kejadian hipertensi. Oleh karena itu, dilakukan penelitian tentang pengembangan Zig Zag Card Remind sebagai media nutrisi bagi penderita hipertensi di Puskesmas Labruk Kidul Lumajang. Metode penelitian ini menggunakan penelitian Research and Development (R&D) dengan menggunakan model ADDIE (Analyze, Design, Development, Implementation, Evaluation). Jumlah subjek dalam penelitian ini adalah 50 pasien hipertensi di Puskesmas Labruk Kidul yang diambil secara accidental sampling. Hasil penelitian pengembangan media zigzag card pengingat bagi penderita hipertensi dari uji kelayakan oleh ahli materi sebesar 95% dan ahli media 92%, hasil tersebut termasuk kategori layak pada uji coba lapangan tanpa revisi maka hasil uji kelayakan media sebesar 83,78 %, artinya produk tersebut sangat cocok digunakan sebagai media edukasi gizi. Disarankan agar produk pengingat kartu zig-zag ini digunakan sebagai media pendidikan untuk kepentingan penelitian kesehatan lebih lanjut yang melibatkan tindakan intervensi pendidikan bagi orang lain.
Objective: to evaluate the efficacy of Allium sativum, Curcuma mangga, and Acorus calamus extract combination on female rat fertility. Methods: Thirty-six female rats were randomized divided into 9 groups (n=4): C-(no treatment); C+ (clomiphene citrate); composition 1 (A. sativum 36%: C. mangga 36%: A. calamus 28%) with 3 doses i.e T1, T2 & T3 of 50, 75 & 100 mg/kg BW; composition 2 (A. sativum 35%: C. mangga 40%: A. calamus 25%) with 3 doses i.e T4, T5 & T6 of 50, 75 & 100 mg/kg BW and T7 (Subur Kandungan herb™). Treatment was given every day for 15 days. Results: The results revealed that all treatments affected reproductive hormone and uterine histology profile. However, T1 produced the highest estrogen and progesterone levels, and T2 produced the highest endometrial and myometrium thickness, as well as the number of endometrial glands. Furthermore, the hormonal profile in T1 and histological profile of uterus in T2 were not significantly different from those of T7 group. Conclusions: Combined A. sativum, C. mangga, and A. calamus extracts could be used to increase fertility in female rat. The most effective treatment in this study was dose of 50-75 mg/BW in both compositions.
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