Objectives: This paper sought to understand and determine the cytotoxic's effects of crude extract and its fraction from Calotropis gigantea leaves on human colon cancer WiDr cell lines. Methods:The ethanolic extract was fractionated gradually with certain substances to yield four fractions. The substances were dichloromethane, ethyl acetate, and butanol. The four fractions resulted in dichloromethane fraction, ethyl acetate fraction, butanol fraction, and a water fraction. These fractions were then investigated for their cytotoxic effects on WiDr cells. The cell viability was assessed using MTT colorimetric assay. Results:The result indicated that the cytotoxic effects of the ethanolic extract (IC5048.5 μg/ml), ethyl acetate fraction (IC5041.79 μg/ml), and dichloromethane fraction (IC5040.57μg/ml) produced a much more potent effect than the butanol fraction (IC50 737.74 μg/ml) and water fraction (IC50 Conclusion:The ethanolic extract, ethyl acetate fraction and dichloromethane fraction exhibited a potent cytotoxic effect on human colon cancer WiDr cell line. The crude extract and fractions are potential to be developed as an anticancer agent in colon cancer therapy.8493 μg/ml).
<p>Malariais one of theinfectious diseaseis stillaproblem ofthe world withhigh mortality. Therapeutic purpose of uncomplicated malariais to eliminateplasmodiumcause infection to preventinfectionseverity, complications andbreak the chain oftransmission. While the purpose therapyof severemalaria is to prevent mortality.Recommendedtherapy of malaria isa combination of twoormore antimalarial drugsthat mechanisms actionkillsmalarialparasitesin thebloodand theamount of each drugworks ondifferent receptors. The use ofa combination ofseveralantimalarial drugshas becomea necessityforprevention ofmalariaparasitestrainsthat are resistantto certain drugs. Combination therapyinclude:ACTs(artemisinin combinationtherapies); artesunateandamodiaquin; artesunateandmefloquin; artesunatewith oneof theSP, lumefantrin, piperaquin, pyronaridin; antibiotic(doxyciclin, clindamycine, azithromycin), artemether-lumefantrine (AL); chloroquineandSP;atovaquoneandproguanil (Malarone)</p>
This research aims to find out the anticancer activity of ethanol extract from the roots, leaves, and flowers of Calotropis gigantea. This experiment was conducted by MTT method on T47D breast cancer cell line. The result showed that the root of Calotropis gigantea was more cytotoxic (IC50 89.76 μg/mL) on T47D breast cancer cell line than the leaves (IC50 459.51 μg/mL) and the flowers (IC50>1000). Based on the result, roots are potent to be chemotherapeutic agent, especially in breast cancer.
EVIDENCE BASED KURKUMIN DARI TANAMAN KUNYIT (Curcuma longa) SEBAGAI TERAPI KANKER PADA PENGOBATAN MODERN Roihatul MutiahJurusan Farmasi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang Indonesia ABSTRAK Kurkumin (diferuloylmethane (C 21 H 20 O 6 ) merupakan komponen berwarna kuningorange yang terkandung dalam tanaman Curcuma longa. Secara tradisional masyarakat Indonesia memanfatkan bagian rimpang tanaman tersebut sebagai salah satu komponen bumbu masakkan sehari-hari dan sebagai komponen jamu dari berbagai kondisi dan penyakit seperti panas, hepatitis, jerawat, infekasi bakteri, inflamasi, scabies dll. Studi in vivo dan in vitro menunjukkan bahwa kurkumin mempunyai berbagai aktivitas farmakologis antara lain antiinflamasi, antiviral, antibakteri, antifungal,antikanker, antioksidan, antidiabetes mellitus, antirheumatoid arthritis. Sedangkan studi klinik juga telah banyak dilakukan diantaranya pada kanker pancreas, kanker kolon, kanker payudara, dan multiple myeloma. Pada makalah ini penulis akan membahas tentang etnomedisin kunyit (Curcuma longa), studi pre-klinik baik secara in vitro maupun in vivo, studi klinik pada pasien dan mekanisme kerja senyawa kurkumin sebagai agen kemopreventif dan kemoterapi penyakit kanker.Kata Kunci :Kurkumin. Curcuma longa, antikanker, evidence based
Students as well as the next intellectual generation in society is not limited to academic obligations in the campus environment, but also should be useful in a variety of other functions in society. Students are also required to participate in community service through various forms of devotion. In this community service, lecturers with students to jointly work devotion in advancing knowledge and skills Tengger tribe in Ngadas Village District of Poncokusumo in developing the potential of medicinal plants and agricultural products based ethnopharmacy towards the creation of an independent village. Ngadas village is village with abundant natural resources, especially medicinal plants and agricultural products. Medicinal plants rare owned by the village is pronojiwo (Euchresta horsfieldii), pulosari (Alyxia reinwardtii), sintok (Cinnamomum sintoc), purwoceng (Pimpinella pruatjan), krangean (Litsea cububa Pers), flour muscles (Borreria laevis Griseb.), guava wer (Prunus persica Bl.), dringu (Acorus calamus L.). Medicinal plants have the potential to be developed and produced in large quantities in this village. Natural wealth of agricultural products is also very abundant in this village include potato, cassava, sweet potatoes and celery. But not taken into ready to eat foods products. Performed community service on 19 November 2016 in the village hall Ngadas. The activities carried out in the form of workshops begins with exposure of the material on the benefits and applications of potential medicinal plants that become local wisdom in Tengger tribe and then followed by demo making products. The product are rub medicine guava wer, muscle flour, starfruit herbal drinks and bajigur. Participants consisted of PKK Ngadas village. Good response shown by them with great enthusiasm when exposure of the material provided and when making products. In the future, this mentoring program to be developed into entrepreneurial activities of local communities to improve their welfare.
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