Background. Psoriasis is associated with a high impact on health-related QoL (quality of life). PUVAsol has been successfully used for treating psoriasis instead of standard PUVA therapy in developing countries. However, data for PUVAsol therapy and its effect on QoL in psoriatic patients is meagre. Objective. To investigate the effect of PUVAsol on the quality of life in patients having chronic plaque psoriasis. Materials and Methods. An observational prospective study done in patients having chronic plaque psoriasis. PASI and DLQI were calculated before initiating treatment with oral PUVAsol. These were compared with the respective scores after 12 weeks of regular treatment with PUVAsol. Statistical analysis was done using SPSS version 20.0. Results. Both PASI and DLQI showed statistically significant reduction after 12 weeks of regular treatment. 90% of patients responded favourably to PUVAsol therapy in the study and all the domains of DLQI showed significant reduction except domain of “work and school.” Conclusion. Our results show that regular PUVAsol treatment improves the physical appearance of disease as evident by decrease in PASI scores. It also improves the QoL of the patients. This study will add upon the growing evidence of efficacy of PUVAsol.

Abstract

The combination of isotretinoin with PUVAsol is more effective compared with PUVAsol alone for treating chronic plaque psoriasis.

Background: Fungi are oral commensal in about half of general population and its largest proportion is made up of Candida species. Candida causes wide variety of infections in human beings. Objectives: To evaluate the prevalence of Candida species in root canals and oral cavities of children and adults. Material and methods: Swabs from oral cavities of 100 patients were collected and subjected to culture on Sabourad's dextrose agar and chromogenic Candida differential agar. Results: Prevalence of oral candida in healthy children and adults belonging to control group was 8% and 4% respectively. Prevalence rate of Candida in root canals of children was 4 (16%) and in adults 1(4%). Out of 50 samples collected from oral cavities of children, 6 (12%) were positive for Candida comprising of 5(83%) Candida albicans and 1(17%) Candida tropicalis. From 50 adult subjects, only 2 samples were positive for Candida i.e 1(4%) Candida parapsilosis and 1(4%) Candida albicans. Conclusion: Candida albicans was found to be the most common isolated species of Candida from the oral cavity in children with or without caries. Hence, presence of carious lesion has no effect on Candidial colonization of oral cavity in both children and adults.

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