Vitiligo although a cosmetic disease without any symptoms, it carry a significant social stigma especially in Indian society. Data interpretation in this study indicates that vitiligo affects QOL in majority of vitiligo patients and such patients require more aggressive and empathic attitude from a dermatologist to cure/improve this so called chronic cosmetic disease.

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Bowens' disease (BD) is a precancerous condition of skin and/or mucosa with a predilection towards sun-exposed areas. Extensive literature research failed to reveal any case of multiple pigmented BD in type V Fitzpatrick skin. Multiple BD is a therapeutic challenge with a tendency to recur. Here we present an otherwise healthy Indian male having multiple pigmented lesions of BD on sun-protected sites of the body mimicking malignant melanoma. These lesions were refractory to treatment with different modalities. This paper is an attempt to review the available literature regarding the pigmented variant of multiple BD. Rationale for a therapeutic trial of UVB therapy for multiple arsenic induced BD is also discussed.

suggestive of collodion membrane at birth. Child started developing tonic-clonic seizures by 6 months of age. He developed eye contact and started holding his head at 6 months of age. He started sitting at 12 months of age. He was operated for right-sided inguinal hernia at the age of 11 months. At presentation, he was unable to speak monosyllables.On physical examination, weight was 7 kg, length was 68 cm and head circumference was 39 cm (all <3 rd percentile for age). He had a prominent forehead with large ears [ Figure 1]. Cutaneous examination revealed nonscarring alopecia over the scalp and eyebrows. Skin over the abdomen was rough in texture due to multiple, spiny, uniformly distributed, white follicular projections [ Figure 2]. Skin over the scalp, face and shin had irregular icthyotic patches. Palms, soles, dentition, oral cavity, genitalia and nails appeared normal. Ophthalmic examination was normal except marked photophobia. Routine hematological and biochemical investigations were normal. Skeletal survey, electrocardiogram, ultrasonography of the abdomen, brainstem evoked auditory response failed to reveal any abnormality. Computed tomography scan head revealed evidence of subtle loss of the right occipital and parietal subcortical white matter. Skin biopsy [ Figure 3] showed hyperkeratosis in epidermis along with keratotic follicular plugging and thin ABSTRACT Ichthyosis follicularis alopecia photophobia (IFAP) syndrome (OMIM 308205) is a rare genetic disorder characterized by a triad of follicular ichthyosis, congenital atrichia of scalp and photophobia. Until date, only 40 patients have been mentioned in the worldwide literature. The management of this syndrome remains a daunting task because very few case reports have described interventions for treating various clinical features of this entity. We describe IFAP syndrome in an 18-month-old male child, who showed transient improvement in his cutaneous features with oral isotretinoin therapy.

Background. Psoriasis is associated with a high impact on health-related QoL (quality of life). PUVAsol has been successfully used for treating psoriasis instead of standard PUVA therapy in developing countries. However, data for PUVAsol therapy and its effect on QoL in psoriatic patients is meagre. Objective. To investigate the effect of PUVAsol on the quality of life in patients having chronic plaque psoriasis. Materials and Methods. An observational prospective study done in patients having chronic plaque psoriasis. PASI and DLQI were calculated before initiating treatment with oral PUVAsol. These were compared with the respective scores after 12 weeks of regular treatment with PUVAsol. Statistical analysis was done using SPSS version 20.0. Results. Both PASI and DLQI showed statistically significant reduction after 12 weeks of regular treatment. 90% of patients responded favourably to PUVAsol therapy in the study and all the domains of DLQI showed significant reduction except domain of “work and school.” Conclusion. Our results show that regular PUVAsol treatment improves the physical appearance of disease as evident by decrease in PASI scores. It also improves the QoL of the patients. This study will add upon the growing evidence of efficacy of PUVAsol.