Calotropis procera and Calotropis gigantea are medicinal plant having therapeutic value. The leaf extracts of C. procera have been investigated, its pharmacological actions in detail and leaf extracts of C. gigantea were not studied till date. The objective of present work was to find the bioactive constituents present in the ethanolic leaf extract of C. procera and C. gigantea to evaluate their antibacterial and anifungal activities. The major phytochemical groups in C. procera ethanolic leaf extracts were fatty acid ethyl ester (21.36%), palmitic acid ester (10.24%), linoleic acid (7.43%) and amino acid (8.10%) respectively, whereas ethanolic leaf extracts of C. gigantea contain palmitic acid (46.01%), diterpene (26.53%), triterpene (17.39%), linoleic acid (5.13%) as the major phytochemical groups. Ethanol extract of C. procera leaves showed the highest inhibition (11 mm) against Escherichia coli, while ethanolic extract of C. gigantea leaves inhibited Klebsiella (20 mm). These findings will use in new directions in pharmacological investigations.
Symplocos racemosa Roxb., belonging to the family Symplocaceae, is an important medicinal plant. Chemometric profile of chloroform, methanol and ethanol leaf extracts of S. racemosa were performed by hyphenated gas chromatography mass spectrometry (GC/MS) technique. Chemometric profile of leaf extracts revealed the presence of 57 phyto-chemotypes, among them, Erucylamide (15.94%), Vitamin E (8.26%), 10-Heneicosene (8.97%), n-Hexadecanoic acid (5.21%), 1-Heneicosyl formate (5.11%), Tetracosanol (5.36%), 2,4-Hexanedione, 5,5-dimethyl- (11.94%), Linoleic acid (19.30%), Dibutyl phthalate (8.8%) and (Z)-9-Octadecenamide (19.33%) were found to be present in major amount. Eventually, in the present study we have found phenol, alcohol, ketone, alkane and ester as the major group of phytochemotypes in the different leaf extracts of S. racemosa. All these compounds identified by GC/MS analysis were further investigated for their biological activities and it was found that they possess a diverse range of positive pharmacological actions. In future, isolation of individual phyto-chemotypes and subjecting them to biological activity will definitely prove fruitful results in designing a novel drug.
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