Chemometric profile & antimicrobial activities of leaf extract of Calotropis procera and Calotropis gigantea

Abstract

Calotropis procera and Calotropis gigantea are medicinal plant having therapeutic value. The leaf extracts of C. procera have been investigated, its pharmacological actions in detail and leaf extracts of C. gigantea were not studied till date. The objective of present work was to find the bioactive constituents present in the ethanolic leaf extract of C. procera and C. gigantea to evaluate their antibacterial and anifungal activities. The major phytochemical groups in C. procera ethanolic leaf extracts were fatty acid ethyl ester (21.36%), palmitic acid ester (10.24%), linoleic acid (7.43%) and amino acid (8.10%) respectively, whereas ethanolic leaf extracts of C. gigantea contain palmitic acid (46.01%), diterpene (26.53%), triterpene (17.39%), linoleic acid (5.13%) as the major phytochemical groups. Ethanol extract of C. procera leaves showed the highest inhibition (11 mm) against Escherichia coli, while ethanolic extract of C. gigantea leaves inhibited Klebsiella (20 mm). These findings will use in new directions in pharmacological investigations.

Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract of Calotropis-gigantean-Mediated Silver Nanoparticles

“…Previously, the anti-candidal action of AgNPs was found to be improved using a combination with commercially available amphotericin b against five Candida species [23]. Thus, our data identified C. gigantea leaf extract as a source of bioactive antifungal compounds that could contribute in the extracellular synthesis of AgNPs, and has a stronger antifungal action than the previously designated antifungal effect [14,56,57].…”

An Overview of the Characteristics and Potential of Calotropis procera From Botanical, Ecological, and Economic Perspectives

“…The major phytochemical groups reported in the leaf extracts of C. procera are fatty acid ethyl esters (21.4%), palmitic acid esters (10.2%), linoleic acids (7.4%), and amino acids (8.1%) (Pattnaik et al, 2017). High-Performance Liquid Chromatography (HPLC) analysis of the leaves and bark ascertained the presence of total phenolic content (20.41-100.18 gallic acid equivalent mg g −1 dry weight), total flavonoid content (IC 50 18.33-92.92 catechin equivalent mg g −1 dry weight), sinapic acid (17.3 ± 2.11 to 9586.44 ± 0.78 mg kg −1 ), vanillic acid (9.43 ± 0.21 to 5051.7 ± 18.47 mg kg −1 ) and protocatechuic acid (2.46 ± 0.40 to 139.05 ± 1.37 mg kg −1 ) (Mehmood et al, 2020).…”

Polyaniline-coated Calotropis procera L. hollow tubular fibers with remarkable antibacterial activity

“…In addition, digestive properties [13] have been attributed to its flowers. Pattnaik et al [14] reported that these medicinal properties arise from phytochemical groups observed in leaf extracts of C. procera: fatty acid ethyl ester, palmitic acid ester, linoleic acid, and amino acids. It is worth mentioning that, to our knowledge, all of the antibacterial and medicinal activities of C. procera derivatives have been associated with ethanolic extracts from parts of the plants.…”