Rh(iii)-Catalyzed substituent enabled alkylation and alkenylation of 1,4-naphthoquinones with maleimides under acidic and basic conditions is described.
A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa-9df) were designed, synthesized, and evaluated for their in vitro Pancreatic Lipase (PL) inhibitory potential that may lead to efficient anti-obesity agents....
The rhodium(III)-catalyzed direct C−H addition and annulation of benzimidates and aldimines with β-(trifluoromethyl)-α,β-unsaturated ketones is described. This protocol provides the facile and efficient formation of various trifluoromethyl-containing indenamines or aminoindanes in moderate to high yields.I ndenes and indanes are very important carbocyclic derivatives that are found in various natural products and pharmaceutically active molecules. 1 Moreover, they find application in organometallics and material science. 2 In particular, aminoindene/indane derivatives have shown important biological activities, 3 such as glutamate receptor antagonist, calcium antagonist, and anti-Parkinson. In addition, trifluoromethyl-containing indane acts as a selective CB2 ligand (Figure 1). 4
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