Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids

Abstract

Recent advances in quinazoline/quinazolinone hybrid heterocycles in medicinal chemistry and their pharmacological diversification.

Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry

“…Quinazolinone is one of the derivatives of quinazoline which is active like quinazoline [8]. Based on the substitution pattern, quinazolinones are further divided into subcategories such as 2-quinazolinone (a) and 4-quinazolinone (b) as shown in Figure 1 [9].…”

Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

“…Quinazolone is the main skeleton of many natural products 8,9 , for example Allicin C, Cyclosporin F, Rutaecarpine, and (þ)-Changshanine (Figure 1). These compounds have a wide range of biological activities, including antitumor, antibacterial, antiviral, and anti-inflammatory [10][11][12] .…”

Enantioselective PCCP Brønsted acid-catalyzed aminalization of aldehydes

“…Nitrogen-containing heterocyclic compounds are commonly occurring in nature and constitute the core structures of many biologically important compounds. An important example of such heterocycles are 2,3-dihydroquinazolinones which scaffold can be found in various compounds exhibiting pharmacological properties [1][2][3][4][5][6]. Some of them are currently used to treat numerous diseases, such as the diuretic drug fenquizone used for the treatment of hypertension [7,8], or evodiamine, a stimulant used in fat reduction or inflammation [9][10][11].…”