Nitric oxide (NO) works as a signaling molecule, toxicant, and antioxidant in the body’s physiological and pathological processes. JS-K is designed to be activated by glutathione-S-transferase (GST) and release NO in a sustained and controlled manner within the tumor cells. JS-K also promotes apoptosis in cancer cells through mitogen-activated protein kinase (MAPK) pathway, ubiquitin-proteasome pathway, cell factor β-catenin/T (TCF) signaling pathway, and other mechanisms. In future studies, we should further develop new NO precursors, so that new drugs in the treatment of cancer can become more efficient, more accurate, and have less adverse reactions.
The mandible is a single bone that makes the lower third of the face and forms peripheral boundaries of floor of the mouth. Surgical resection of mandible owing to benign, malignant neoplasm, osteoradionecrosis is common. Loss of mandibular continuity causes deviation and rotation inferiorly due to muscle pull and scar contracture affecting mandibular movements, mastication, speech and aesthetics. Case Report: This case report describes prosthetic rehabilitation of a patient with post hemi-mandibulectomy residual defect. Patient underwent surgical resection of mandible right side distal to canine resulted in deviation and rotation of mandible towards the defect side. Because of restricted manipulation of mandible towards non-resected side, dual occlusion prosthesis in maxillary arch was planned to improve masticatory efficiency. Conclusion: Patients with excessive scar contracture limits mandibular manipulation towards normal side to achieve occlusion. These patients are rehabilitated with dual occlusion prosthesis to restore function.
Introduction:The implant-retained overdenture has been advocated as an effective method of rehabilitating the edentulous patient that offers significant benefits over conventional prosthesis. It is important to understand the etiological factors responsible in causing failures and complications during the various clinical procedures associated with the use of this treatment modality. This knowledge aids treatment planning, communicating with the patient, informed consent, and posttreatment care of the implants and prostheses. Case report: This paper outlines a clinical case demonstrating common complications encountered in implant retained overdentures and suggests how these complications can be managed. Conclusion: Failure of implant has a multifactorial dimension. Often many factors come together to cause the ultimate failure of the implant.
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