Background: A significant number of oral cancer cases present initially with precursor lesions. If detected earlier in disease course it will reduce the morbidity and mortality. The objective of this study was to evaluate the clinical presentation and various histopathological types of premalignant lesions.Methods: This is descriptive, observational, analytical type of study of five-year duration. The detail clinical presentation, relevant investigation and histopathological study on biopsy tissue stain with H and E was done and the data is analysed.Results: During study period, 173 cases having oral lesions were observed. Among these 38 cases showed oral premalignant lesions. The most common age group affected was in between 50 to 59 years. The male predominance was noted. Male to female ratio was 1.9:1. The location of the lesions were buccal mucosa (55.26%), tongue (26.31%), gingiva (7.90%), alveolus (5.26%), lip (2.6%), retromolar area (2.63%) was noted. The common etiological factor observed was tobacco chewing. On histopathological features, cases were of leukoplakia 68.41%, oral lichen planus 13.16%, oral submucous fibrosis 7.90%, actinic cheilitis-7.9%, and oral erythroplakia 2.6%.Conclusions: In this study, various oral premalignant lesions were observed. Their clinical and histopathological evaluation was done. Oral leukoplakia was most common lesion in the present study. Buccal mucosa was the most common site. Tobacco chewing habit was the common risk factor observed. Early detection of premalignant oral lesion is of utmost importance to prevent further morbidity as these lesions further progress to oral cancer.
A study on Clinicopathological Study Of Renal Tumours In Surgically Excised Specimens was conducted for two years from June 2016 to May 2018. The study was on twenty-eight surgically excised specimens of renal tumours in the Department of Pathology of Krishna Institute of Medical Sciences at Karad District in Satara, Maharastra, India. The observed results stood as 75% of Radical Nephrectomy, 17.85% of renal biopsies and partial Nephrectomy in 7.14% cases. The reading revealed 28.5% of cases, that is, a maximum number were found in their 6th decade of life. The rest of the cases, 21.42% were either septuagenarian or quadragenarian. The male preponderance was noted with Male: Female ratio 2.5:1. Out of 28 cases of renal tumours, 50% of cases had flank pain, 28.57% cases with flank pain associated with hematuria in A maximum number of instances had issues that were involving the left-sided kidney. The most common site for tumour involvement was upper pole comprising of 35.71% followed by the lower pole in 28.57% of cases. In a maximum number of instances, grossly the size of tumour ranged from 0-4 cm. Out of all malignant tumours, Renal Cell Carcinoma-RCC was the most common tumour comprising (75%). The majority (42.10%) of renal cell carcinomas were of Fuhrman nuclear grade II. Majority of cases (56.5%) were at TNM stage I. A detailed histopathology examination and routine H and E staining help - to diagnose accurately and to determine the various histological type, subtype. It also helps to evaluate other histopathological determinants. The clinical results shifts as per the histologic subtypes.
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