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Ultra-high stable chitosan functionalized gold nanoparticles (GNPs) of desired biopolymeric corona are synthesized without adding conventional hazardous reducing agents. The inherent unique set of properties like reducing ability, stabilizing effect, and mucoadhesiveness of chitosan is exhibited in the present work. Morphologies and ultra-stability of the synthesized materials are characterized by standard techniques. The mucoadhesiveness of the synthesized materials are well documented through the biological potency of the synthesized GNPs. The prominent bioactivity is evident from the antifilarial activity. The cellular and molecular level studies on the induction of oxidative stress, DNA damage, and undesirable protein expression clearly explain the antifilarial activities. Interestingly, the developed nanoparticle shows no detectable sign of toxicity when evaluated in vitro (rat peritoneal MФ) or in vivo (Wistar rat). Therefore, the synthesized green GNPs appear to be a substantial promise as an efficacious broad-spectrum nanotherapeutic agent with safe outcome for clinical attempt.

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